重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2014年
30期
4016-4018,4021
,共4页
心力衰竭%左室重构%心脏再同步化治疗%左室容积指数%左房容积指数
心力衰竭%左室重構%心髒再同步化治療%左室容積指數%左房容積指數
심력쇠갈%좌실중구%심장재동보화치료%좌실용적지수%좌방용적지수
heart failure%ventricular remodeling%cardiac resynchronization therapy%left ventricular volume index%left atrial vol-ume index
目的:旨在评价心脏再同步化治疗(CRT )对左房结构和功能的影响。方法选择2011年6月至2013年12月在本院心内科施行CRT治疗慢性心力衰竭的患者14例,其中男8例,女6例,所有患者均接受起搏器植入、CRT优化及规范的药物治疗,并随访6个月临床与超声指标[包括治疗前后的左心室收缩末期容积指数(LVESVi)和左心室舒张末期容积指数(LVED-Vi)、左房最大容积指数(iLAVmax)、心房收缩前左房容积指数(iLAVpre)及左房最小容积指数(iLAVmin)等]。LVESVi降低幅度大于10%被视为CRT治疗有反应。结果 CRT治疗反应者(71.4%)与无反应者(28.6%)具有相似的基线特征和左室容积指数,但CRT治疗有反应者iLAVmax更低(P<0.05)。CRT 显著降低 LVESVi(P<0.01)、LVEDVi(P<0.01)、iLAVmax(P=0.004)、iLAVpre(P=0.003)和iLAVmin(P<0.01),但与无反应者相比,治疗有反应者iLAVmax降低更显著。相关分析显示LVEDVi与iLAVmax、iLAVmin显著相关(P<0.05)。结论 CRT治疗能够显著改善iLAVpre ,iLAVmax可能成为逆转左室重构的潜在预测因素。
目的:旨在評價心髒再同步化治療(CRT )對左房結構和功能的影響。方法選擇2011年6月至2013年12月在本院心內科施行CRT治療慢性心力衰竭的患者14例,其中男8例,女6例,所有患者均接受起搏器植入、CRT優化及規範的藥物治療,併隨訪6箇月臨床與超聲指標[包括治療前後的左心室收縮末期容積指數(LVESVi)和左心室舒張末期容積指數(LVED-Vi)、左房最大容積指數(iLAVmax)、心房收縮前左房容積指數(iLAVpre)及左房最小容積指數(iLAVmin)等]。LVESVi降低幅度大于10%被視為CRT治療有反應。結果 CRT治療反應者(71.4%)與無反應者(28.6%)具有相似的基線特徵和左室容積指數,但CRT治療有反應者iLAVmax更低(P<0.05)。CRT 顯著降低 LVESVi(P<0.01)、LVEDVi(P<0.01)、iLAVmax(P=0.004)、iLAVpre(P=0.003)和iLAVmin(P<0.01),但與無反應者相比,治療有反應者iLAVmax降低更顯著。相關分析顯示LVEDVi與iLAVmax、iLAVmin顯著相關(P<0.05)。結論 CRT治療能夠顯著改善iLAVpre ,iLAVmax可能成為逆轉左室重構的潛在預測因素。
목적:지재평개심장재동보화치료(CRT )대좌방결구화공능적영향。방법선택2011년6월지2013년12월재본원심내과시행CRT치료만성심력쇠갈적환자14례,기중남8례,녀6례,소유환자균접수기박기식입、CRT우화급규범적약물치료,병수방6개월림상여초성지표[포괄치료전후적좌심실수축말기용적지수(LVESVi)화좌심실서장말기용적지수(LVED-Vi)、좌방최대용적지수(iLAVmax)、심방수축전좌방용적지수(iLAVpre)급좌방최소용적지수(iLAVmin)등]。LVESVi강저폭도대우10%피시위CRT치료유반응。결과 CRT치료반응자(71.4%)여무반응자(28.6%)구유상사적기선특정화좌실용적지수,단CRT치료유반응자iLAVmax경저(P<0.05)。CRT 현저강저 LVESVi(P<0.01)、LVEDVi(P<0.01)、iLAVmax(P=0.004)、iLAVpre(P=0.003)화iLAVmin(P<0.01),단여무반응자상비,치료유반응자iLAVmax강저경현저。상관분석현시LVEDVi여iLAVmax、iLAVmin현저상관(P<0.05)。결론 CRT치료능구현저개선iLAVpre ,iLAVmax가능성위역전좌실중구적잠재예측인소。
Objective To prospectively assess the association between cardiac resynchronization therapy (CRT )and left atrial volume .Methods Fourteen patients with chronic heart failure ,sinus rhythm and left bundle branch block were enrolled in this study and prepared for CRT implantation .Clinical and echocardiographic evaluations were performed before CRT implantation and 6 months later .Followings were parameters of the left atrial and left ventricular volume:left ventricular end-systolic volume index (LVESVi)and end-diastolic volume index(LVEDVi) ,maximal LAV index(iLAVmax) ,etc ,LAV index before atrial systole(iL-AVpre)and minimal LAV(iLAVmin) .CRT responders were defined as those whose reduction rates were more than 10% in iL-VESV in 6-month follow-up .Results Responders(71 .4% )and non-responders(28 .6% )had similar baseline ,clinical characteristics and pre-implantation LV volumes .However ,iLAVmax in the responders was remarkably lower than that in non-responders .CRT therapy significantly reduced LVESVi(P<0 .01) ,LVEDVi(P<0 .001) ,iLAVmax(P=0 .004) ,iLAVpre(P=0 .003)and iLAVpost (P<0 .01) ,but when compared with the non-responders ,iLAVmax was much lower in responders .Correlation analysis showed that there was a significant correlation of LVEDVi with iLAVmax ,iLAVpost(P<0 .05) .Conclusion CRT therapy can significant-ly improve iLAVpre and iLAVmax may be a predictor of LV reverse remodeling .