重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2014年
30期
10-12
,共3页
脓毒症%血小板活化因子%氢化可的松%相关性%预后
膿毒癥%血小闆活化因子%氫化可的鬆%相關性%預後
농독증%혈소판활화인자%경화가적송%상관성%예후
sepsis%platelet activating factor%hydrortisone%correlation%prognosis
目的：探讨脓毒症患者血浆血小板活化因子（PAF）与皮质醇（Cor）水平的相关性，以及二者与患者预后的关系。方法选择2012年4月至2013年8月期间由重庆市急救医疗中心IC U收治的脓毒症患者102例为脓毒症组，健康志愿者40例为对照组。按脓毒症患者住院期间的预后情况，将其分为存活组及死亡组，比较对照组、脓毒症存活组及死亡组患者血浆 PA F及Cor水平，比较脓毒症存活组及死亡组患者急性生理和慢性健康评分Ⅱ（APACHEⅡ），分析对照组、脓毒症存活组及死亡组患者血浆PAF与Cor水平的相关性。结果脓毒症存活组及死亡组患者血浆PAF、Cor水平较对照组均明显增高（P＜0．05），脓毒症死亡组患者血浆PAF、Cor水平及APACHEⅡ较存活组明显增高（P＜0．05）；对照组血浆 PAF与Cor水平相关性不显著（P＞0．05），而脓毒症存活组及死亡组患者血浆PAF与Cor水平均呈正相关（P＜0．05）；受试者工作特征（ROC）曲线分析显示，PAF 、Cor及APACHEⅡ可作为脓毒症患者住院期间死亡的预测指标（曲线下面积分别为0．708、0．715、0．787）。结论脓毒症患者血浆PAF与Cor水平呈正相关，二者对评估患者住院期间的预后情况具有一定指导意义。
目的：探討膿毒癥患者血漿血小闆活化因子（PAF）與皮質醇（Cor）水平的相關性，以及二者與患者預後的關繫。方法選擇2012年4月至2013年8月期間由重慶市急救醫療中心IC U收治的膿毒癥患者102例為膿毒癥組，健康誌願者40例為對照組。按膿毒癥患者住院期間的預後情況，將其分為存活組及死亡組，比較對照組、膿毒癥存活組及死亡組患者血漿 PA F及Cor水平，比較膿毒癥存活組及死亡組患者急性生理和慢性健康評分Ⅱ（APACHEⅡ），分析對照組、膿毒癥存活組及死亡組患者血漿PAF與Cor水平的相關性。結果膿毒癥存活組及死亡組患者血漿PAF、Cor水平較對照組均明顯增高（P＜0．05），膿毒癥死亡組患者血漿PAF、Cor水平及APACHEⅡ較存活組明顯增高（P＜0．05）；對照組血漿 PAF與Cor水平相關性不顯著（P＞0．05），而膿毒癥存活組及死亡組患者血漿PAF與Cor水平均呈正相關（P＜0．05）；受試者工作特徵（ROC）麯線分析顯示，PAF 、Cor及APACHEⅡ可作為膿毒癥患者住院期間死亡的預測指標（麯線下麵積分彆為0．708、0．715、0．787）。結論膿毒癥患者血漿PAF與Cor水平呈正相關，二者對評估患者住院期間的預後情況具有一定指導意義。
목적：탐토농독증환자혈장혈소판활화인자（PAF）여피질순（Cor）수평적상관성，이급이자여환자예후적관계。방법선택2012년4월지2013년8월기간유중경시급구의료중심IC U수치적농독증환자102례위농독증조，건강지원자40례위대조조。안농독증환자주원기간적예후정황，장기분위존활조급사망조，비교대조조、농독증존활조급사망조환자혈장 PA F급Cor수평，비교농독증존활조급사망조환자급성생리화만성건강평분Ⅱ（APACHEⅡ），분석대조조、농독증존활조급사망조환자혈장PAF여Cor수평적상관성。결과농독증존활조급사망조환자혈장PAF、Cor수평교대조조균명현증고（P＜0．05），농독증사망조환자혈장PAF、Cor수평급APACHEⅡ교존활조명현증고（P＜0．05）；대조조혈장 PAF여Cor수평상관성불현저（P＞0．05），이농독증존활조급사망조환자혈장PAF여Cor수평균정정상관（P＜0．05）；수시자공작특정（ROC）곡선분석현시，PAF 、Cor급APACHEⅡ가작위농독증환자주원기간사망적예측지표（곡선하면적분별위0．708、0．715、0．787）。결론농독증환자혈장PAF여Cor수평정정상관，이자대평고환자주원기간적예후정황구유일정지도의의。
Objective To investigate the correlation of platelet activating factor(PAF)with cortisol(Cor) ,as well as their rela-tionship with patients after sepsis prognosis .Methods 102 patients with sepsis admitted in the ICU of Chongqing Emergency Med-ical Center from April 2012 to August 2013 were enrolled into sepsis group ,and 40 cases of volunteers served as control group .All the patients were divided into survival group and non-survival group ,according to their prognosis during hospitalization .Plasma PAF and Cor level in control group ,survival group and non-survival group were compared with each other ,and acute physiology and chronic health evaluationⅡ(APACHEⅡ)in survival group and non-survival group were compared .The correlations of plasma PAF with Cor level in control group ,survival group and non-survival group were analyzed ,respectively .Results Plasma PAF and Cor level in survival group and non-survival group were significantly higher than that in control group(P<0 .05) .Plasma PAF ,Cor lev-el and APACHEⅡ scores were higher in non-survival group than that in survival group(P<0 .05) .The correlation of plasma PAF with Cor level in control group was not significant(P>0 .05) ,while the plasma PAF level positively correlated with Cor level in survival group and non-survival group(P<0 .05) .Curves of receiver operating characteristics(ROC)showed that PAF ,Cor and A-PACHEⅡ score could be used as predictors of mortality during hospitalization(Area=0 .708 ,0 .715 ,0 .787) .Conclusion The plas-ma PAF level positively correlates with Cor level in patient with sepsis .PAF ,Cor and APACHEⅡ score have certain guiding signif-icance for the assessment of prognosis during hospitalization in patients with sepsis .
