护理研究
護理研究
호리연구
NURSING RESEARCH
2014年
31期
3957-3961,3964
,共6页
消化道肿瘤%肠内免疫营养支持%肠外营养支持%感染性并发症%住院时间%系统综述%Meta分析
消化道腫瘤%腸內免疫營養支持%腸外營養支持%感染性併髮癥%住院時間%繫統綜述%Meta分析
소화도종류%장내면역영양지지%장외영양지지%감염성병발증%주원시간%계통종술%Meta분석
gastrointestinal cancer%enteral nutrition support immu-nity%parenteral nutrition support%infectious complications%hospitali-zation time%systematic review%Meta analysis
[目的]系统评价术后肠内免疫营养支持对术后感染性并发症和住院时间的影响。[方法]计算机检索中文全文期刊数据库(CNKI )、万方数据库、维普数据库、PubMed,Medline,Cochran Library,由2位研究者采用Cochrane系统评价法进行评价和数据提取,采用 RevMan5.1软件进行Meta分析。[结果]最终纳入9篇随机对照研究,共800例病人。Meta 分析显示肠内免疫营养支持组和肠外营养组肺部感染发生率[OR=0.61,95%置信区间为(0.35,1.06)]、切口感染发生率[OR=0.71,95%置信区间为(0.37,1.36)]、尿路感染发生率[OR=0.39,95%置信区间为(0.14,1.14)]、腹腔感染发生率[OR=0.48,95%置信区间为(0.22,1.07)]差异均无统计学意义(P>0.05)；两组住院时间加权均数差为-3.13,95%置信区间为(-5.54,-0.71),差异有统计学意义(P<0.05)。[结论]消化道肿瘤病人术后应用肠内免疫营养支持可能不会降低术后常见感染性并发症的发生率,但可能减少病人的住院时间；由于本研究的局限性,可能需要更多高质量的随机对照研究和 Meta分析结果来验证。
[目的]繫統評價術後腸內免疫營養支持對術後感染性併髮癥和住院時間的影響。[方法]計算機檢索中文全文期刊數據庫(CNKI )、萬方數據庫、維普數據庫、PubMed,Medline,Cochran Library,由2位研究者採用Cochrane繫統評價法進行評價和數據提取,採用 RevMan5.1軟件進行Meta分析。[結果]最終納入9篇隨機對照研究,共800例病人。Meta 分析顯示腸內免疫營養支持組和腸外營養組肺部感染髮生率[OR=0.61,95%置信區間為(0.35,1.06)]、切口感染髮生率[OR=0.71,95%置信區間為(0.37,1.36)]、尿路感染髮生率[OR=0.39,95%置信區間為(0.14,1.14)]、腹腔感染髮生率[OR=0.48,95%置信區間為(0.22,1.07)]差異均無統計學意義(P>0.05)；兩組住院時間加權均數差為-3.13,95%置信區間為(-5.54,-0.71),差異有統計學意義(P<0.05)。[結論]消化道腫瘤病人術後應用腸內免疫營養支持可能不會降低術後常見感染性併髮癥的髮生率,但可能減少病人的住院時間；由于本研究的跼限性,可能需要更多高質量的隨機對照研究和 Meta分析結果來驗證。
[목적]계통평개술후장내면역영양지지대술후감염성병발증화주원시간적영향。[방법]계산궤검색중문전문기간수거고(CNKI )、만방수거고、유보수거고、PubMed,Medline,Cochran Library,유2위연구자채용Cochrane계통평개법진행평개화수거제취,채용 RevMan5.1연건진행Meta분석。[결과]최종납입9편수궤대조연구,공800례병인。Meta 분석현시장내면역영양지지조화장외영양조폐부감염발생솔[OR=0.61,95%치신구간위(0.35,1.06)]、절구감염발생솔[OR=0.71,95%치신구간위(0.37,1.36)]、뇨로감염발생솔[OR=0.39,95%치신구간위(0.14,1.14)]、복강감염발생솔[OR=0.48,95%치신구간위(0.22,1.07)]차이균무통계학의의(P>0.05)；량조주원시간가권균수차위-3.13,95%치신구간위(-5.54,-0.71),차이유통계학의의(P<0.05)。[결론]소화도종류병인술후응용장내면역영양지지가능불회강저술후상견감염성병발증적발생솔,단가능감소병인적주원시간；유우본연구적국한성,가능수요경다고질량적수궤대조연구화 Meta분석결과래험증。
Obj ective:To systematically evaluate the influence of postoper-ative intestinal immune nutritional support on postoperative infectious complications and hospitalization time.Methods:The CNKI,Wangfang datebase,VIP datebase,PubMed,Medline and Cochran Library were searched by computers.Two investigators used Cochrane system evalua-tion method to evaluate and extract data,and all the data were analyzed with RevMan5 .1 .Software.Results:A total of nine randomized controlled trials involving 800 patients met the inclusion criteria.The results showed that there were no significantly statistical differences in the rate of pulmo-nary infection[OR=0.61,95%CI(0.35,1.06)]、incision infection[OR=0.71,95%CI(0.37,1.36)]、urinary tract infection[OR=0.39,95%CI(0.14, 1.14)]、abdominal infection[OR=0.48,95%CI(0.22,1.07)]be-tween both groups (P>0.05).There was significantly statistical differ-ence in length of stay in hospital[WMD=-3.13,95%CI(-5.54,-0.71)] (P<0.05).Conclusion:The postoperative application of enteral im-mune nutrition support for gastrointestinal cancer patients may not reduce the incidence of postoperative common infectious complica-tions,but it maybe shrink the length of hospital stay.Limited to the study,more high quality RCTs and Meta analysis are required to ver-ify the effects.
