CAJ | 학술논문

目的：通过对贫血患者进行平均红细胞体积（MCV）和红细胞脆性及血红蛋白电泳检测，研究临床诊断珠蛋白生成障碍性贫血的正确方法，从而避免和防止珠蛋白生成障碍性贫血漏诊问题的发生。方法选取2011年8月至2012年8月门诊及住院治疗的80例珠蛋白生成障碍性贫血患者与60例非珠蛋白生成障碍性贫血患者，进行 MCV、红细胞脆性试验和血红蛋白电泳检测。结果分别进行 MCV、红细胞脆性及血红蛋白电泳的单项检测，对珠蛋白生成障碍性贫血诊断的灵敏度和特异度分别是90．1％、77．4％、71．2％和70．2％、91．1％、91．9％；进行 MCV、红细胞脆性及血红蛋白电泳联合检测，其灵敏度和特异度是100％、61．8％。单项的 MCV、红细胞脆性及血红蛋白电泳的阳性例数分别为71例、58例和51例，联合检测阳性数为48例。结论MCV 与红细胞脆性试验，血红蛋白电泳的单项检测，虽然对珠蛋白生成障碍性贫血进行临床检测和筛查具有十分重要的意义和价值，然而对部分珠蛋白生成障碍性贫血患者，其单项检测也会显现正常的结果，因此在临床、产前的筛查当中，联合检测要比单项检测具有优越性。进行 MCV 和红细胞脆性及血红蛋白电泳的联合检测，对于及时、正确地诊断珠蛋白生成障碍性贫血，有效地避免和防止漏诊问题，具有十分重要的意义和作用。
목적：통과대빈혈환자진행평균홍세포체적（MCV）화홍세포취성급혈홍단백전영검측，연구림상진단주단백생성장애성빈혈적정학방법，종이피면화방지주단백생성장애성빈혈루진문제적발생。방법선취2011년8월지2012년8월문진급주원치료적80례주단백생성장애성빈혈환자여60례비주단백생성장애성빈혈환자，진행 MCV、홍세포취성시험화혈홍단백전영검측。결과분별진행 MCV、홍세포취성급혈홍단백전영적단항검측，대주단백생성장애성빈혈진단적령민도화특이도분별시90．1％、77．4％、71．2％화70．2％、91．1％、91．9％；진행 MCV、홍세포취성급혈홍단백전영연합검측，기령민도화특이도시100％、61．8％。단항적 MCV、홍세포취성급혈홍단백전영적양성례수분별위71례、58례화51례，연합검측양성수위48례。결론MCV 여홍세포취성시험，혈홍단백전영적단항검측，수연대주단백생성장애성빈혈진행림상검측화사사구유십분중요적의의화개치，연이대부분주단백생성장애성빈혈환자，기단항검측야회현현정상적결과，인차재림상、산전적사사당중，연합검측요비단항검측구유우월성。진행 MCV 화홍세포취성급혈홍단백전영적연합검측，대우급시、정학지진단주단백생성장애성빈혈，유효지피면화방지루진문제，구유십분중요적의의화작용。
Objective During compared single detection and combined detection of mean corpuscular volume (MCV),red cell osmotic fragility(RBC brittle)and hemoglobin electrophoresis to explore the correct method for clinical diagnosis of thalassemia,so as to avoid and prevent the occurrence of missed diagnosis of thalassemia.Methods Eighty thalassemia patients and 60 non Mediterranean anemia patients were chose from August 2011 to August 2012,comparative analyze the single detection and combined detection of MCV,RBC brittle and hemoglobin electro-phoresis.Results The sensitivity and specificity of diagnosis about the single detection of MCV,RBC brittle and he-moglobin electrophoresis were 90.1%,77.4%,71.2% and 70.2%,91.1%,91.9%;the sensitivity and specificity a-bout the combined detection of MCV,fragility of erythrocyte and hemoglobin electrophoresis were 100%,61.8%. The number of positive cases of single MCV,RBC fragile and hemoglobin electrophoresis detection were 71 cases,58 cases and 51 cases,48 cases was the positive number of the combined detection.Conclusion Although The single de-tection of MCV,RBC fragile and hemoglobin electrophoresis have a very important value to the Mediterranean anemi-a,for part of Mediterranean anemia patients the single test would increase the missed diagnosis rate,so the combined detection was superior to the single detection.Combined detection of MCV,RBC fragile and hemoglobin electrophore-sis have important meaning and for the timely,accurate diagnosis of thalassemia and avoiding missed diagnosis problem.