CAJ | 학술논문

目的：对比不同民族慢性阻塞性肺疾病（COPD）患者凝血及纤溶指标的差异。方法采集2012年1月至2013年12月收治于新疆维吾尔自治区人民医院呼吸科的122例维吾尔族，160例汉族 COPD 患者及50例健康体检者的外周静脉血，测定各研究对象的凝血酶原时间（PT）、活化部分凝血酶原时间（APTT）、血浆纤维蛋白原（Fib）和 D-二聚体（D-D）水平。结果COPD 患者与健康对照组相比，Fib 与 D-D 值明显增高，差异有统计学意义（P ＜0．05），PT、APTT 亦延长，但差异无统计学意义（P ＞0．05）；维吾尔族与汉族 COPD 患者相比，Fib、D-D 增高， PT、APTT 延长，但差异均无统计学意义（P ＞0．05）。结论不同民族 COPD 患者 PT、APTT、Fib 及 D-D 水平无明显差异，但是监测 COPD 患者体内的各凝血及纤溶指标的水平，可为预防、早期发现和及时治疗 COPD 提供参考。
목적：대비불동민족만성조새성폐질병（COPD）환자응혈급섬용지표적차이。방법채집2012년1월지2013년12월수치우신강유오이자치구인민의원호흡과적122례유오이족，160례한족 COPD 환자급50례건강체검자적외주정맥혈，측정각연구대상적응혈매원시간（PT）、활화부분응혈매원시간（APTT）、혈장섬유단백원（Fib）화 D-이취체（D-D）수평。결과COPD 환자여건강대조조상비，Fib 여 D-D 치명현증고，차이유통계학의의（P ＜0．05），PT、APTT 역연장，단차이무통계학의의（P ＞0．05）；유오이족여한족 COPD 환자상비，Fib、D-D 증고， PT、APTT 연장，단차이균무통계학의의（P ＞0．05）。결론불동민족 COPD 환자 PT、APTT、Fib 급 D-D 수평무명현차이，단시감측 COPD 환자체내적각응혈급섬용지표적수평，가위예방、조기발현화급시치료 COPD 제공삼고。
Objective To compare the difference of coagulation and fibrinolysis indicators in different-nation patients with chronic obstructive pulmonary disease(COPD).Methods The peripheral blood samples were collected from 122 Uygur and 106 Han COPD patients and 50 health person,PT,APTT,Fib and D-D were detected.Results Compared with the health people,Fib and D-D of COPD patients were higher(P <0.05);PT,APTT were also lon-ger,but the differences were not statistically significant.Uygur COPD patients had higher PT,APTT,Fib and DD than Han patients,but the differences had no statistical significance.Conclusion There was no statistical difference between Uygur and Han COPD patients,but the monitoring of coagulation and fibrinolysis indicators could provide reference to prevent,discovery early diagnosis and treat with COPD.