CAJ | 학술논문

目的：探讨超敏 C-反应蛋白（hs-CRP）与不同类型冠心病的相关性。方法选取2009年2月至2012年2月收治的134例冠心病患者，根据患者的冠心病分类，将其分成3个组，其中稳定型心绞痛组患者46例，不稳定型心绞痛组患者52例，急性心肌梗死组患者36例。同时选取100例健康人作为对照组，分别测定并比较三组冠心病患者以及对照组健康人群血清的 hs-CRP 水平。结果稳定型心绞痛组患者 hs-CRP 水平为（5．4±3．1）mg/L；不稳定型心绞痛组患者 hs-CRP 水平为（8．6±4．2）mg/L；急性心肌梗死组患者 hs-CRP 水平为（21．8±10．3）mg/L。三种类型冠心病患者的血清 hs-CRP 水平均高于对照组，差异均有统计学意义（P ＜0．05）；急性心肌梗死组患者的血清 hs-CRP 水平高于不稳定型心绞痛组患者，且两者明显高于稳定型心绞痛组患者，差异均有统计学意义（P ＜0．05）。结论血清 hs-CRP 与冠心病的发生、发展关系密切，对患者血清 hs-CRP 的检测有助于冠心病的早期诊断和预后判断，为临床医生提供依据。
목적：탐토초민 C-반응단백（hs-CRP）여불동류형관심병적상관성。방법선취2009년2월지2012년2월수치적134례관심병환자，근거환자적관심병분류，장기분성3개조，기중은정형심교통조환자46례，불은정형심교통조환자52례，급성심기경사조환자36례。동시선취100례건강인작위대조조，분별측정병비교삼조관심병환자이급대조조건강인군혈청적 hs-CRP 수평。결과은정형심교통조환자 hs-CRP 수평위（5．4±3．1）mg/L；불은정형심교통조환자 hs-CRP 수평위（8．6±4．2）mg/L；급성심기경사조환자 hs-CRP 수평위（21．8±10．3）mg/L。삼충류형관심병환자적혈청 hs-CRP 수평균고우대조조，차이균유통계학의의（P ＜0．05）；급성심기경사조환자적혈청 hs-CRP 수평고우불은정형심교통조환자，차량자명현고우은정형심교통조환자，차이균유통계학의의（P ＜0．05）。결론혈청 hs-CRP 여관심병적발생、발전관계밀절，대환자혈청 hs-CRP 적검측유조우관심병적조기진단화예후판단，위림상의생제공의거。
Objective To investigate the correlation between serum high- sensitivity C- reactive protein and the different kind of coronary heart disease.Methods From February 2009 to February 2012,134 cases patients diag-nosed with coronary heart disease were divided into three groups:stable angina(46 cases),unstable angina(52 cases) and acute myocardial infarction(36 cases),100 cases of healthy people were chose as a control group,to measure and compare the serum high-sensitivity C-reactive protein levels of three groups of patients with coronary artery disease and the control group of healthy human.Results The serum high-sensitivity C-reactive protein levels of control group was(1.6±0.4)mg/L;the serum high-sensitivity C-reactive protein levels of unstable angina was(5.4±3.1) mg/L;the serum high-sensitivity C-reactive protein levels of stable angina was(8.6±4.2)mg/L;the serum high-sen-sitivity C-reactive protein levels of acute myocardial infarction was(5.4±3.1)mg/L;The serum high-sensitivity C-re-active protein levels of different types of coronary heart disease patients were higher than that of the control group, the data were statistically significant different(P <0.05);the serum high sensitivity C-reactive protein levels of acute myocardial infarction in patients was significantly higher in unstable angina patients,the difference was statistically significant(P < 0.05).The serum high-sensitivity C-reactive protein of unstable angina patients was significantly higher than that of the stable angina group,the difference was statistically significant(P <0.05).Conclusion There is a close relationship between the serum high sensitivity C-reactive protein levels and the occurrence and development of coronary heart disease.Detecting the serum high sensitivity C-reactive protein levels is helpful for early diagnosis of coronary heart disease and prognosis,it can provide a reference for clinical treatment.