CAJ | 학술논문

目的：探讨肝硬化患者血脂水平和血小板参数的相关性，以及综合分析判断的临床价值。方法取明确诊断的肝硬化患者48例为肝硬化组，健康体检人员50例为对照组，分别检测两组人员的血脂水平与血小板参数，并进行相关性分析。结果肝硬化患者较健康者血清总胆固醇（CHO）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL）、血清载脂蛋白 A1和 B（ApoA1和 ApoB）均有明显的下降（P ＜0．05）。肝硬化组血小板计数（PLT）、血小板压积（PCT）、平均血小板体积（MPV）降低明显，差异均有统计学意义（P ＜0．01）。结论肝硬化患者伴有血小板参数变化及血脂合成障碍、代谢紊乱，具有很好的相关性。综合分析，对于了解肝脏的损害程度，及时掌握患者的病程进程，为预后判断及治疗提供有效的科学依据。
목적：탐토간경화환자혈지수평화혈소판삼수적상관성，이급종합분석판단적림상개치。방법취명학진단적간경화환자48례위간경화조，건강체검인원50례위대조조，분별검측량조인원적혈지수평여혈소판삼수，병진행상관성분석。결과간경화환자교건강자혈청총담고순（CHO）、삼선감유（TG）、고밀도지단백담고순（HDL-C）、저밀도지단백담고순（LDL）、혈청재지단백 A1화 B（ApoA1화 ApoB）균유명현적하강（P ＜0．05）。간경화조혈소판계수（PLT）、혈소판압적（PCT）、평균혈소판체적（MPV）강저명현，차이균유통계학의의（P ＜0．01）。결론간경화환자반유혈소판삼수변화급혈지합성장애、대사문란，구유흔호적상관성。종합분석，대우료해간장적손해정도，급시장악환자적병정진정，위예후판단급치료제공유효적과학의거。
Objective To explore the correlation between blood lipid levels and platelet parameters in patients with cirrhosis,comprehensive analyze and judge the clinical value.Methods Forty eight patients with cirrhosis were divided into cirrhosis group,50 cases healthy people were divided into control group,testing blood lipid level and platelet parameters in two groups,and analyze the correlation.Results The levels of serum total cholesterol(CHO), glycerin three fat(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL),ser-um apolipoprotein A1 and B(ApoA1 and ApoB)of cirrhosis patients were significantly low than that of healthy peo-ple(P < 0.05).Cirrhosis group platelet count(PLT),platelet hematocrit(PCT),mean platelet volume(MPV)de-creased significantly with control group,the difference was significant(P <0.01).Conclusion There is a good corre-lation between the changes of platelet parameters and abnormal metabolism of serum lipids in patients with cirrhosis. Comprehensive,understanding liver damage,grasping patient′s disease process,have important reference value to pro-vide effective scientific basis for prognosis and therapy.