CAJ | 학술논문

目的：探讨就诊人群中抗环瓜氨酸肽（CCP）抗体、抗角蛋白抗体（AKA）、抗 RA33抗体、磷酸6葡萄糖异构酶（GPI）、类风湿因子（RF）等类风湿关节炎相关抗体的阳性分布趋势，及其在不同疾病中的分布与临床应用价值。方法用固相酶联免疫吸附法（ELISA）检测抗 CCP 抗体、抗 RA33抗体、磷酸6葡萄糖异构酶（GPI）、用间接免疫荧光法检测 AKA，用免疫比浊法检测 RF。结合患者临床资料分析这些自身抗体在不同年龄、性别和疾病中的阳性分布趋势及临床应用价值。结果抗 CCP 抗体、AKA、抗 RA33抗体、GPI、RF 例就诊人群的阳性率分别为26．22％、6．65％、7．13％、41．19％、32．95％；女性中抗 RA33抗体阳性率高于男性，男性抗 CCP 抗体阳性率高于女性（P ＜0．05）。在 RA 患者组各种抗体阳性率明显高于其他组，且抗体滴度也明显高于其他组。结论抗 CCP 抗体、AKA、抗 RA33抗体、GPI、RF 主要见于类风湿关节炎患者，但是也可出现在其他疾病中，但滴度较低。因此在临床诊疗过程需综合分析，应避免片面根据自身抗体检查结果所致误诊。
목적：탐토취진인군중항배과안산태（CCP）항체、항각단백항체（AKA）、항 RA33항체、린산6포도당이구매（GPI）、류풍습인자（RF）등류풍습관절염상관항체적양성분포추세，급기재불동질병중적분포여림상응용개치。방법용고상매련면역흡부법（ELISA）검측항 CCP 항체、항 RA33항체、린산6포도당이구매（GPI）、용간접면역형광법검측 AKA，용면역비탁법검측 RF。결합환자림상자료분석저사자신항체재불동년령、성별화질병중적양성분포추세급림상응용개치。결과항 CCP 항체、AKA、항 RA33항체、GPI、RF 례취진인군적양성솔분별위26．22％、6．65％、7．13％、41．19％、32．95％；녀성중항 RA33항체양성솔고우남성，남성항 CCP 항체양성솔고우녀성（P ＜0．05）。재 RA 환자조각충항체양성솔명현고우기타조，차항체적도야명현고우기타조。결론항 CCP 항체、AKA、항 RA33항체、GPI、RF 주요견우류풍습관절염환자，단시야가출현재기타질병중，단적도교저。인차재림상진료과정수종합분석，응피면편면근거자신항체검사결과소치오진。
Objective To explore the positive distribution of anti-cyclic citrullinated peptide(CCP)antibody, anti-keratin antibody(AKA),anti-RA33 antibody,glucose-6-phosphate isomerase(GPI),rheumatoid factors(RF)in population with rheumatoid arthritis,and to evaluate the association between these distributions and disease diagno-sis.Methods Anti-CCP antibody,anti-RA33 antibody,and GPI were measured by solid enzyme-linked immunosor-bent assay(ELISA).AKA was detected by indirect immunofluorescence assay.RF was determined by immunoturbidi-metric assay.The positive distribution of these autoantibodies in population of different ages,genders and diseases, and their clinical significance were investigated in combination with the clinical data of the patients.Results The pos-itive rate of Anti-CCP antibody,AKA,anti-RA33 antibody,GPI,and RF:26.22%,6.65%,7.13%,41.19%, 32.95%,respectively.The positive rate of anti-RA33 antibodywas higher in female than in male.The positive rate of patients with rheumatoid arthritis(RA)was significantly higher than that of any other diseases.Conclusion Anti-CCP antibody,AKA,anti-RA33 antibody,GPI,and RF were mainly detected in patients with RA.However,low-titer autoantibodies were also found in patients with other diseases.In clinical diagnosis and treatment process,we should analyze comprehensively the specific conditions of patients in order to avoid misdiagnosis.