CAJ | 학술논문

目的：探讨幽门螺杆菌（Hp）感染与2型糖尿病（T2DM）患者并发冠心病（CHD）的相关性。方法选择120例临床确诊的 T2DM 患者作为观察对象，其中51例患者合并 CHD（T2DM＋CHD 组），69例单纯 T2DM患者（单纯 T2DM 组）；另选择60例健康志愿者作为正常对照组。采用胶体金法检测幽门螺杆菌（Hp-IgG）抗体，并对结果进行统计学分析。结果T2DM 患者 Hp-IgG 抗体检出率（49．17％）明显高于对照组（31．67％），差异具有统计学意义（P ＜0．01）；T2DM＋CHD 组患者 Hp-IgG 抗体的检出率（64．71％）明显高于单纯 T2DM 组（36．23％， P ＜0．01）和对照组（P ＜0．01）。T2DM 合并 Hp 感染者的 CHD 发病率（55．93％）明显高于非 Hp 感染者（29．51％， P ＜0．01）。T2DM 患者并发 CHD 与 Hp 感染呈显著正相关（r＝0．203，t＝2．715，P ＜0．01）。结论T2DM 患者并发 CHD 与 Hp 感染具有相关性，清除或预防 Hp 感染可能是防止 T2DM 患者并发 CHD 的有效措施。
목적：탐토유문라간균（Hp）감염여2형당뇨병（T2DM）환자병발관심병（CHD）적상관성。방법선택120례림상학진적 T2DM 환자작위관찰대상，기중51례환자합병 CHD（T2DM＋CHD 조），69례단순 T2DM환자（단순 T2DM 조）；령선택60례건강지원자작위정상대조조。채용효체금법검측유문라간균（Hp-IgG）항체，병대결과진행통계학분석。결과T2DM 환자 Hp-IgG 항체검출솔（49．17％）명현고우대조조（31．67％），차이구유통계학의의（P ＜0．01）；T2DM＋CHD 조환자 Hp-IgG 항체적검출솔（64．71％）명현고우단순 T2DM 조（36．23％， P ＜0．01）화대조조（P ＜0．01）。T2DM 합병 Hp 감염자적 CHD 발병솔（55．93％）명현고우비 Hp 감염자（29．51％， P ＜0．01）。T2DM 환자병발 CHD 여 Hp 감염정현저정상관（r＝0．203，t＝2．715，P ＜0．01）。결론T2DM 환자병발 CHD 여 Hp 감염구유상관성，청제혹예방 Hp 감염가능시방지 T2DM 환자병발 CHD 적유효조시。
Objective To explore the correlation of helicobacter pylori (Hp)infection and T2DM accompan-ying with Coronary heart disease (CHD).Methods One hundred and twenty patients with T2DM were chose and di-vided into T2DM group (69 cases)and T2DM with CHD group (T2DM+CHD)(51 cases),another 60 health peo-ple were chose to be control group.detect serum Hp-IgG antibody by colloidal gold method,a statistical comparison used to analyze the result.Results The positive rate of Hp-IgG(+)antibody among 120 T2DM patients (49.17%) was significantly higher than that of the control group(31.67%)(P <0.01),The positive rate of Hp-IgG(+)anti-body of the T2DM+CHD group(64.71%)was significantly higher than that of T2DM group(36.23%,P <0.01) and that of the control group(P <0.01).The positive rate of Hp-IgG(+)antibody of the combination of T2DM Hp infection and CHD group(55.93%)was significantly higher than that of the Hp infection group(29.51%,P <0.01).The positive rate of Hp-IgG(+)antibody ofT2DM with CHD group was significantly associated with Hp in-fection(r=0.203,t=2.715,P <0.01).Conclusion T2DM accompanying with CHD was associated with Hp infec-tion,removing or preventing Hp infection might be one of the strategies to prevent and treat of T2DM accompanying with CHD.