检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2014年
z1期
266-268,269
,共4页
张玲%王雯娟%谢婉冰%翁海斌%纪文玲
張玲%王雯娟%謝婉冰%翁海斌%紀文玲
장령%왕문연%사완빙%옹해빈%기문령
不孕不育%抗精子抗体%抗子宫内膜抗体%抗心磷脂抗体%抗卵巢抗体
不孕不育%抗精子抗體%抗子宮內膜抗體%抗心燐脂抗體%抗卵巢抗體
불잉불육%항정자항체%항자궁내막항체%항심린지항체%항란소항체
infertility%anti-spermantibodies%anti-endometrialantibodies%anti-cardiolipi-n antibodies%anti-ovarian antibodies
目的：探讨抗精子抗体（AsAb）、抗心磷脂抗体（AcAb）、抗子宫内膜抗体（EMAb）、抗卵巢抗体（AO-Ab）、抗透明带抗体（AZPAb）、抗滋养层细胞膜抗体（TAAb）、抗 HCG 抗体检测在原发性性不孕不育妇女中的应用价值。方法采用 ELISA 法检测13840例女性不孕不育患者进行血清中 AsAb、AcAb、EMAb、AOAb、ZP-Ab、TAAb、抗 HCG 抗体，同时与健康组作对比研究。结果不孕不育组 AsAb、AcAb、EMAb、AOAb、AZPAb、TAAb、抗 HCG 抗体的阳性率分别为29．17％、1．5％、3％、1．4％、0．4％、0．4％、0．2％，健康组 AsAb、AcAb、EMAb、AO-Ab、AZPAb、TAAb、抗 HCG 抗体的阳性率分别为1％、0．2％、0．1％、0．1％、0％、0％、0％；两组结果中，AsAb、AcAb、EMAb、AOAb 结果差异有统计学意义（P ＜0．01）；而 AZPAb、TAAb、抗 HCG 抗体结果差异无统计学意义（P ＞0．05）。结论AsAb、AcAb、EMAb、AOAb 是引起女性原发性不孕不育的重要免疫因素，不孕不育者应进行免疫性抗体的检测，而 AZPAb、TAAb、抗 HCG 抗体在原发性免疫性不孕不育患者中不是重要的免疫因素。
目的：探討抗精子抗體（AsAb）、抗心燐脂抗體（AcAb）、抗子宮內膜抗體（EMAb）、抗卵巢抗體（AO-Ab）、抗透明帶抗體（AZPAb）、抗滋養層細胞膜抗體（TAAb）、抗 HCG 抗體檢測在原髮性性不孕不育婦女中的應用價值。方法採用 ELISA 法檢測13840例女性不孕不育患者進行血清中 AsAb、AcAb、EMAb、AOAb、ZP-Ab、TAAb、抗 HCG 抗體，同時與健康組作對比研究。結果不孕不育組 AsAb、AcAb、EMAb、AOAb、AZPAb、TAAb、抗 HCG 抗體的暘性率分彆為29．17％、1．5％、3％、1．4％、0．4％、0．4％、0．2％，健康組 AsAb、AcAb、EMAb、AO-Ab、AZPAb、TAAb、抗 HCG 抗體的暘性率分彆為1％、0．2％、0．1％、0．1％、0％、0％、0％；兩組結果中，AsAb、AcAb、EMAb、AOAb 結果差異有統計學意義（P ＜0．01）；而 AZPAb、TAAb、抗 HCG 抗體結果差異無統計學意義（P ＞0．05）。結論AsAb、AcAb、EMAb、AOAb 是引起女性原髮性不孕不育的重要免疫因素，不孕不育者應進行免疫性抗體的檢測，而 AZPAb、TAAb、抗 HCG 抗體在原髮性免疫性不孕不育患者中不是重要的免疫因素。
목적：탐토항정자항체（AsAb）、항심린지항체（AcAb）、항자궁내막항체（EMAb）、항란소항체（AO-Ab）、항투명대항체（AZPAb）、항자양층세포막항체（TAAb）、항 HCG 항체검측재원발성성불잉불육부녀중적응용개치。방법채용 ELISA 법검측13840례녀성불잉불육환자진행혈청중 AsAb、AcAb、EMAb、AOAb、ZP-Ab、TAAb、항 HCG 항체，동시여건강조작대비연구。결과불잉불육조 AsAb、AcAb、EMAb、AOAb、AZPAb、TAAb、항 HCG 항체적양성솔분별위29．17％、1．5％、3％、1．4％、0．4％、0．4％、0．2％，건강조 AsAb、AcAb、EMAb、AO-Ab、AZPAb、TAAb、항 HCG 항체적양성솔분별위1％、0．2％、0．1％、0．1％、0％、0％、0％；량조결과중，AsAb、AcAb、EMAb、AOAb 결과차이유통계학의의（P ＜0．01）；이 AZPAb、TAAb、항 HCG 항체결과차이무통계학의의（P ＞0．05）。결론AsAb、AcAb、EMAb、AOAb 시인기녀성원발성불잉불육적중요면역인소，불잉불육자응진행면역성항체적검측，이 AZPAb、TAAb、항 HCG 항체재원발성면역성불잉불육환자중불시중요적면역인소。
Objective Explore the application value of anti-sperm antibodies,anti-cardiolipin antibodies,anti-endometrial antibodies,anti-ovarian antibodies,anti- zona pellucida antibodies,anti- trophoblast cell antibody,anti-HCG antibody in Primary infertility.Methods ELISA was used to detect the anti-sperm antibodies,anti-cardiolipin antibodies,anti-endometrial antibodies,anti-ovarian antibodies,anti- zona pellucida antibodies,anti- trophoblast cell antibody,anti-HCG antibody in 13 840 cases of infertility patients,then compared the results with healthy person.Re-sults In infertility group the positive rates of these antibodies were 29.17%,1.5%,3%,1.4%,0.4%,0.4%,0.2%respectively,while in healthy group the positive rates were 1%、0.2%、0.1%、0.1%、0%、0%、0% respectively. There was significant difference between the two group in the results of anti-sperm antibodies,anti-cardiolipin anti-bodies,anti-endometrial antibodies,anti-ovarian antibodies(P <0.01),however,there were no difference in anti-zona pellucida antibodies,anti-trophoblast cell antibody,anti-HCG antibody.Conclusion Anti-sperm antibodies,anti-car-diolipin antibodies,anti-endometrial antibodies,anti-ovarian antibodies are important immune factors which cause women primary infertility,so infertility patients should detect autoimmune antibodies,but for infertility patients anti-zona pellucida antibodies,anti-trophoblast cell antibody,anti-HCG antibody are not the important immune factors.
