CAJ | 학술논문

目的：探讨 Survivin 在肾细胞癌（RCC）患者手术前后外周血液中的表达变化及其意义。方法采用双抗体夹心酶联免疫吸附试验（ELISA）检测30例 RCC 行肾癌根治术患者和10例非肿瘤原因切肾患者术前1 d、术后第7天外周血中 Survivin 含量表达变化情况。结果10例非肿瘤原因切肾患者术前1 d、术后第7天外周血中Survivin 的含量分别为（10．90±14．69）pg/mL、（5．00±10．58）pg/mL；30例 RCC 患者术前1 d、术后第7天外周血中 Survivin 的含量分别为（125．80±49．28）pg/mL、（31．53±23．70）pg/mL。对照组术前、术后相比，差异无统计学意义（P ＞0．05）。RCC 组术前、术后相比，术后明显下降，差异有统计学意义（P ＜0．05）。对照组与 RCC 组相比，术前术后相比差异均有统计学意义（P ＜0．05）。结论肾细胞癌根治术后，Survivin 在外周血中含量随之明显下降，进一步说明了 Survivin 与 RCC 的预后有一定的关系。测定外周血中 Survivin 含量可作为监测肿瘤发生和预后的一个重要指标，将有助于肿瘤的早期诊断和预后的评估。
목적：탐토 Survivin 재신세포암（RCC）환자수술전후외주혈액중적표체변화급기의의。방법채용쌍항체협심매련면역흡부시험（ELISA）검측30례 RCC 행신암근치술환자화10례비종류원인절신환자술전1 d、술후제7천외주혈중 Survivin 함량표체변화정황。결과10례비종류원인절신환자술전1 d、술후제7천외주혈중Survivin 적함량분별위（10．90±14．69）pg/mL、（5．00±10．58）pg/mL；30례 RCC 환자술전1 d、술후제7천외주혈중 Survivin 적함량분별위（125．80±49．28）pg/mL、（31．53±23．70）pg/mL。대조조술전、술후상비，차이무통계학의의（P ＞0．05）。RCC 조술전、술후상비，술후명현하강，차이유통계학의의（P ＜0．05）。대조조여 RCC 조상비，술전술후상비차이균유통계학의의（P ＜0．05）。결론신세포암근치술후，Survivin 재외주혈중함량수지명현하강，진일보설명료 Survivin 여 RCC 적예후유일정적관계。측정외주혈중 Survivin 함량가작위감측종류발생화예후적일개중요지표，장유조우종류적조기진단화예후적평고。
Objective To study the expression and significance of Survivin in Pre/Post operative peripheral blood of renal cell carcinoma(RCC).Methods The content of Survivin in Pre/Post operative peripheral blood of 30 patients with RCC and 10 nontumorous patients were detected by enzyme linked immunosorbent assay(ELISA).Re-sults The content of Survivin in peripheral blood in30 cases of RCC preoperative one day was (125.80±49.28)pg/mL.While the content postoperative one week was (31.53±23.70)pg/mL.Comparing with the content of preopera-tive one day,the content of postoperative one week was in decreasing trend.There was no statistically significant difference in Pre/Post operative of 10 nontumorous patients(P <0.05).Conclusion The expression of Suvrivin in peripheral blood of RCC patients was significantly decreasing after operation.It suggests that Survivin is tightly relat-ed with the tumor′s progress.Therefore,Detecting the expression of Suvrivin in peripheral blood of RCC patients could lay an important role in diagnosing and forecasting of tumor recurrence after operation of RCC.