CAJ | 학술논문

目的：探讨血清特异性 IgE（sIgE）检测在婴幼儿湿疹及儿童特应性皮炎诊断中的临床意义。方法采用欧蒙印迹法检测707例婴幼儿湿疹（647例）及儿童特应性皮炎（60例）患儿血清中吸入性和食物过敏原 sIgE。结果本研究样本中引起血清 sIgE 升高的吸入性过敏原主要为尘螨组合和屋尘，食物过敏原主要为鸡蛋白。不同年龄段患儿对应的主要致敏原不同，3岁以内者鸡蛋白 sIgE 阳性率高于其他年龄组，3～6岁以及6岁以上者尘螨和屋尘 sIgE 阳性率高于3岁以下，差异均具有统计学意义。合并鼻炎或哮喘的特应性皮炎患儿与单纯婴幼儿湿疹患儿相比，屋尘过敏更多见（P ＝0．004）。结论尘螨组合、屋尘和鸡蛋白等吸入性和食物性过敏原是引起婴幼儿湿疹及儿童特应性皮炎的重要原因。早期采取有效环境控制，对于预防婴幼儿湿疹及儿童特应性皮炎的发生非常重要。
목적：탐토혈청특이성 IgE（sIgE）검측재영유인습진급인동특응성피염진단중적림상의의。방법채용구몽인적법검측707례영유인습진（647례）급인동특응성피염（60례）환인혈청중흡입성화식물과민원 sIgE。결과본연구양본중인기혈청 sIgE 승고적흡입성과민원주요위진만조합화옥진，식물과민원주요위계단백。불동년령단환인대응적주요치민원불동，3세이내자계단백 sIgE 양성솔고우기타년령조，3～6세이급6세이상자진만화옥진 sIgE 양성솔고우3세이하，차이균구유통계학의의。합병비염혹효천적특응성피염환인여단순영유인습진환인상비，옥진과민경다견（P ＝0．004）。결론진만조합、옥진화계단백등흡입성화식물성과민원시인기영유인습진급인동특응성피염적중요원인。조기채취유효배경공제，대우예방영유인습진급인동특응성피염적발생비상중요。
Objective To investigate the clinical application of serum specific IgE in children with eczema or atopic dermatitis(AD).Methods The total IgE and specific IgE for aero-and food-allergens were determined by line immunoassay(EUROLINE system,EUROIMMUN)in 707 children with eczema or AD.Results The primary com-mon aeor-allergens were dust mite and house dust;the most common food-allergen was egg white.Children in differ-ent age groups were found allergic to different allergens.The positive rate of sIgE to egg white was significantly high-er in children under 3-year old than the other age groups,and the positive rates of sIgE to dust mite and house dust significantly increased with age.Compared to children only with eczema,children with AD and accompanying rhinitis or asthma were allergic to house dust more commonly(P =0.004).Conclusion It′s suggested that aero-allergens and food-allergens such as dust mite,house dust and egg white are important causes to induce eczema and AD in children. The early effective improvement of the environment will be necessary for the management and preventions of AD in children.