检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2014年
z1期
231-233
,共3页
血液灌流%血液透析%尿毒症%顽固性皮肤瘙痒%临床效果
血液灌流%血液透析%尿毒癥%頑固性皮膚瘙癢%臨床效果
혈액관류%혈액투석%뇨독증%완고성피부소양%림상효과
hemodialysis%hemoperfusion%uremia%intractable skin%clinical effect
目的：探讨血液灌流（HP）与血液透析（HD）串联治疗尿毒症顽固性皮肤瘙痒的临床效果。方法选取2012年6月至2014年2月收治的维持性透析的尿毒症患者63例，并随机分为两组，其中采用灌流器与透析器串联（HP＋HD）进行治疗的为观察组，共33例；单纯进行血液透析治疗的为对照组（HD 组），共30例；分别观察两组患者治疗后的临床症状和生活质量的改善情况。结果观察组患者治疗后β2-MG 和 PTH 分别下降至（47．6±48．5）mg/L、（665．6±586．6）pg/mL；治疗前后比较差异有统计学意义（P ＜0．05）；皮肤瘙痒缓解率为90．9％。对照组患者治疗后β2-MG 和 PTH 分别下降至（53．6±49．3）mg/L、（798．6±642．0）pg/mL；治疗前后比较差异有统计学意义（P ＜0．05），皮肤瘙痒缓解率为33．3％。HP＋HD 组患者的症状改善情况明显优于对照组。结论血液灌流联合血液透析治疗尿毒症顽固性皮肤瘙痒能有效消除β2-MG 和 PTH，缓解皮肤瘙痒症状，改善患者的生活质量，是解决尿毒症患者皮肤瘙痒的有效手段之一，值得推广应用。
目的：探討血液灌流（HP）與血液透析（HD）串聯治療尿毒癥頑固性皮膚瘙癢的臨床效果。方法選取2012年6月至2014年2月收治的維持性透析的尿毒癥患者63例，併隨機分為兩組，其中採用灌流器與透析器串聯（HP＋HD）進行治療的為觀察組，共33例；單純進行血液透析治療的為對照組（HD 組），共30例；分彆觀察兩組患者治療後的臨床癥狀和生活質量的改善情況。結果觀察組患者治療後β2-MG 和 PTH 分彆下降至（47．6±48．5）mg/L、（665．6±586．6）pg/mL；治療前後比較差異有統計學意義（P ＜0．05）；皮膚瘙癢緩解率為90．9％。對照組患者治療後β2-MG 和 PTH 分彆下降至（53．6±49．3）mg/L、（798．6±642．0）pg/mL；治療前後比較差異有統計學意義（P ＜0．05），皮膚瘙癢緩解率為33．3％。HP＋HD 組患者的癥狀改善情況明顯優于對照組。結論血液灌流聯閤血液透析治療尿毒癥頑固性皮膚瘙癢能有效消除β2-MG 和 PTH，緩解皮膚瘙癢癥狀，改善患者的生活質量，是解決尿毒癥患者皮膚瘙癢的有效手段之一，值得推廣應用。
목적：탐토혈액관류（HP）여혈액투석（HD）천련치료뇨독증완고성피부소양적림상효과。방법선취2012년6월지2014년2월수치적유지성투석적뇨독증환자63례，병수궤분위량조，기중채용관류기여투석기천련（HP＋HD）진행치료적위관찰조，공33례；단순진행혈액투석치료적위대조조（HD 조），공30례；분별관찰량조환자치료후적림상증상화생활질량적개선정황。결과관찰조환자치료후β2-MG 화 PTH 분별하강지（47．6±48．5）mg/L、（665．6±586．6）pg/mL；치료전후비교차이유통계학의의（P ＜0．05）；피부소양완해솔위90．9％。대조조환자치료후β2-MG 화 PTH 분별하강지（53．6±49．3）mg/L、（798．6±642．0）pg/mL；치료전후비교차이유통계학의의（P ＜0．05），피부소양완해솔위33．3％。HP＋HD 조환자적증상개선정황명현우우대조조。결론혈액관류연합혈액투석치료뇨독증완고성피부소양능유효소제β2-MG 화 PTH，완해피부소양증상，개선환자적생활질량，시해결뇨독증환자피부소양적유효수단지일，치득추엄응용。
Objective To study the clinical effect of hemoperfusion(HP)combined with hemodialysis(HD)on the patients with intractable skin pruritus of uremia.Methods A total of 63 patients with maintenance dialysis ure-mia were enrolled as research objects from June 2012 to February 2014,all patients were randomly divided into two groups.There were 33 cases in the observation group who treated with hemoperfusion combined with hemodialysis;There were 30 case in the control group who treated with conventional hemodialysis.Recorded and analyzed the two groups with improvement of quality of life and clinical effect.Results β2-MG and PTH of the patients in observation group dropped to 47.6 ± 48.5,665.6±586.6 after treatment respectively;Before and after treatment with signifi-cant difference(P <0.05);Itchy skin remission rate was 90.9%.β2-MG and PTH of the patients in control group dropped to 53.6 ±49.3,49.3± 642.0 after treatment respectively;There was significant difference before and after treatment(P <0.05),the skin itch relief rate was 33.3%.The symptoms of observation group improved significantly better than that of the control group.Conclusion The hemoperfusion combined with hemodialysis for treating intrac-table skin pruritus of uremia can get better to clear theβ2-MG and PTH of patients′body,alleviate symptoms of itchy skin,improve the patient′s quality of life,it is one of the effective means to treat itchy skin of uremia and is worthy of popularizing as clinical application.
