CAJ | 학술논문

目的：评价血清降钙素原（PCT）浓度在败血症早期诊断中的临床价值。方法搜集2013年被诊断为败血症的患者327例（患者个体间无亲缘关系），对其检测的 PCT 值和血液培养结果采用 Mann-Whitney U 检验以及 ROC 曲线进行统计分析。结果（1）PCT 在血培养阳性、阴性组之间差异有统计学意义（U＝6165．500，P ＜0．05）；（2）ROC 曲线下面积为0．811，95％可信区间为0．759～0．863，标准误为0．027，可诊断为败血症的 PCT 最佳值为0．507 ng/mL，此时约登指数最大，灵敏度为0．801，特异度为0．314。结论PCT 检测值用于判断败血阴性和阳性有意义，且 PCT 检测值越大预示血培养阳性的可能性越大，因此，PCT 浓度监测可快速地明确患者是否发生细菌感染，为进一步治疗提供参考依据。如果单纯用 PCT 检测值诊断败血症，其特异度较低，尚需联合其他诊断方法。
목적：평개혈청강개소원（PCT）농도재패혈증조기진단중적림상개치。방법수집2013년피진단위패혈증적환자327례（환자개체간무친연관계），대기검측적 PCT 치화혈액배양결과채용 Mann-Whitney U 검험이급 ROC 곡선진행통계분석。결과（1）PCT 재혈배양양성、음성조지간차이유통계학의의（U＝6165．500，P ＜0．05）；（2）ROC 곡선하면적위0．811，95％가신구간위0．759～0．863，표준오위0．027，가진단위패혈증적 PCT 최가치위0．507 ng/mL，차시약등지수최대，령민도위0．801，특이도위0．314。결론PCT 검측치용우판단패혈음성화양성유의의，차 PCT 검측치월대예시혈배양양성적가능성월대，인차，PCT 농도감측가쾌속지명학환자시부발생세균감염，위진일보치료제공삼고의거。여과단순용 PCT 검측치진단패혈증，기특이도교저，상수연합기타진단방법。
Objective To evaluate the clinical value of serum PCT concentrations in the early diagnosis of sep-sis.Methods 327 unrelated patients diagnosed with sepsis were collected in 2013.Then the results of PCT and the blood culture about these patients were analyzed by Mann-Whitney U test and ROC curve.Results (1)The values of PCT between positive and negative blood culture groups had significant difference(U=6 165.500,P <0.05).(2)The area under the ROC curve was 0.811,95% confidence interval for the area was 0.759 to 0.863,the standard error of the area was 0.027.3.The best diagnostic value of PCT for sepsis was 0.507 ng/mL with Youden index in maxi-mum,the sensitivity as 0.801 and the specificity as 0.314.Conclusion The values of PCT between positive and nega-tive sepsis groups have significant difference(P <0.05).The blood culture was more possible positive when the level of PCT was higher.Monitoring PCT for patients with suspected bacterial infection can quickly make a definite diag-nosis,and provide reference for further treatment.