CAJ | 학술논문

随着人口老龄化的加剧，衰老越来越受到人们的重视。衰老主要表现为行为能力、工作能力、肌肉质量以及生殖能力、性行为、性欲的降低，同时还会出现血脂水平增加，认知功能的损伤和睡眠障碍等。衰老相关的临床表现，降低了老年人的生活质量（QoL），其中有很多表现与生长激素缺乏患者的表现相似。近年来关于使用重组人生长激素（rhGH）替代治疗来延缓衰老的研究有很多。研究显示 rhGH 可以改善老年人的生活质量。本文将从生活质量的定义、测量，老年人身体各系统与生长激素（GH）的关系以及rhGH可能的作用机制来阐述rhGH替代治疗对正常老年人生活质量的影响和可行性。
수착인구노령화적가극，쇠로월래월수도인문적중시。쇠로주요표현위행위능력、공작능력、기육질량이급생식능력、성행위、성욕적강저，동시환회출현혈지수평증가，인지공능적손상화수면장애등。쇠로상관적림상표현，강저료노년인적생활질량（QoL），기중유흔다표현여생장격소결핍환자적표현상사。근년래관우사용중조인생장격소（rhGH）체대치료래연완쇠로적연구유흔다。연구현시 rhGH 가이개선노년인적생활질량。본문장종생활질량적정의、측량，노년인신체각계통여생장격소（GH）적관계이급rhGH가능적작용궤제래천술rhGH체대치료대정상노년인생활질량적영향화가행성。
With the increasing population of the aged, more and more people pay attention to aging, which may cause the behavior ability, work ability, muscle mass, the reproductive capacity, sexual behavior and libido to decrease, meanwhile, there will be increased blood lipid level, sleeping disorders, cognitive impairment etc. Aging-related clinical manifestations reduce the older's quality of life (QoL), which are similar to the performance of patients with growth hormone deficiency. There are many researches about using recombinant human growth hormone (rhGH) to slow down the aging progress. Studies have shown that rhGH can improve the QoL of old persons. This paper explained the definition and measurement of QoL, the relationship between the body systems of the old and growth hormone (GH), the possible mechanism of rhGH and the effects and feasibility of rhGH replacement therapy on QoL in normal aged ones.