CAJ | 학술논문

目的：探讨帕利哌酮缓释片与利培酮片治疗酒精所致精神障碍的临床疗效及安全性。方法：共纳入40例酒精所致精神障碍患者进行6周的研究。将患者分为帕利哌酮缓释片组(研究组)和利培酮组(对照组)各20例。在患者治疗前及治疗第1、2、4、6周末采用阳性和阴性症状量表( PANSS)评定临床疗效；治疗中需处理的不良反应量表( TESS)评定不良反应；两组患者均入院即使用相同护肝药物，定期检测肝功能，监测肝功能各项指标变化。结果：两药对酒精所致精神障碍的疗效无显著性差异(P>0.05)；在不良反应方面，帕利哌酮缓释片组患者低于利培酮组，两组患者比较有显著差异(P<0.05)；研究组患者治疗2周后较对照组肝功能改善明显，差异有统计学意义(P<0.05)。结论：帕利哌酮缓释片治疗酒精所致精神障碍疗效显著，不良反应较利培酮轻微，且有助于肝功能改善，值得临床进一步推广运用。
목적：탐토파리고동완석편여리배동편치료주정소치정신장애적림상료효급안전성。방법：공납입40례주정소치정신장애환자진행6주적연구。장환자분위파리고동완석편조(연구조)화리배동조(대조조)각20례。재환자치료전급치료제1、2、4、6주말채용양성화음성증상량표( PANSS)평정림상료효；치료중수처리적불량반응량표( TESS)평정불량반응；량조환자균입원즉사용상동호간약물，정기검측간공능，감측간공능각항지표변화。결과：량약대주정소치정신장애적료효무현저성차이(P>0.05)；재불량반응방면，파리고동완석편조환자저우리배동조，량조환자비교유현저차이(P<0.05)；연구조환자치료2주후교대조조간공능개선명현，차이유통계학의의(P<0.05)。결론：파리고동완석편치료주정소치정신장애료효현저，불량반응교리배동경미，차유조우간공능개선，치득림상진일보추엄운용。
Objective:To investigate the clinical efficacy and safety of Paliperidone ER and Risperidone in treatment of alcohol-induced mental disorder. Methods:40 patients diagnosed with alcohol-induced mental disorder were randomly assigned to study group (20 cases, treated with Paliperidone ER for six weeks) and control group (20 cases, treated with Risperidone for six weeks). The positive and negative syndrome scale ( PANSS) and the treatment emergent symptom scale ( TESS) were used to assess the clinical efficacy and safety at baseline, 1, 2, 4, and 6 weeks after the treatment, respectively. The same liver aid drugs and periodic liver function tests were used to treat the two groups since hospitalization, while various indicators of liver function were monitored. Results:Both Paliperidone ER and Risperidone had equal efficacy in the treatment of alcohol-induced mental disorder, and there was no signifi-cant difference (P>0. 05). The study group had significant less side effects than control group, and the difference was significant (P<0. 05). The study group had more significant improvement in liver function compared to control group 2 weeks after the treatment, and the difference was significant (P<0. 05). Conclusions: Paliperidone ER has good efficacy in the treatment of alcohol-induced mental disorder. It has less side effects than Risperidone and helps the improvement of liver function. Paliperidone ER is worth further clinical application.