CAJ | 학술논문

目的:研究CYP1B1 SNP rs1056827,rs1056836基因多态性与乳腺癌的关联.方法:应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)检测CYP1B1 SNP rs1056827,rs1056836基因多态性,比较乳腺癌患者组与健康志愿者对照组CYP1B1 SNP rs1056827,rs1056836基因型的分布频率差异及等位基因频率差异.结果:120例乳腺癌患者组和127例健康志愿者对照组CYP1B1 SNP rs1056827基因型分布频率野生型GG为48.33/65.35％,杂合型GT为40.83/29.13％,突变型TT为10.83/5.51％,两组比较x2为7.71,0.01＜ P＜0.05,等位基因频率野生型G为68.75/79.92％,突变型T为31.25/20.08％,两组比较x2为8.11,P＜0.01;CYP1B1SNP rs1056836基因型分布频率野生型CC为49.17/66.93％,杂合型CG为37.50/26.77％,突变型GG为13.33/6.29％,两组比较x2为8.70,0.01＜P＜0.05,等位基因频率野生型C为67.92/80.31％,突变型G为32.08/19.68％,二组比较x2为8.73,P＜0.01.结论:乳腺癌患者组与健康志愿者对照组CYP1B1 SNP rs1056827,rs1056836基因型分布频率和等位基因频率差异有显著性,提示乳腺癌的发生可能与CYP1B1 SNP rs1056827,rs1056836基因多态性具有某种关联.
목적:연구CYP1B1 SNP rs1056827,rs1056836기인다태성여유선암적관련.방법:응용취합매련반응-한제성편단장도다태성(PCR-RFLP)검측CYP1B1 SNP rs1056827,rs1056836기인다태성,비교유선암환자조여건강지원자대조조CYP1B1 SNP rs1056827,rs1056836기인형적분포빈솔차이급등위기인빈솔차이.결과:120례유선암환자조화127례건강지원자대조조CYP1B1 SNP rs1056827기인형분포빈솔야생형GG위48.33/65.35％,잡합형GT위40.83/29.13％,돌변형TT위10.83/5.51％,량조비교x2위7.71,0.01＜ P＜0.05,등위기인빈솔야생형G위68.75/79.92％,돌변형T위31.25/20.08％,량조비교x2위8.11,P＜0.01;CYP1B1SNP rs1056836기인형분포빈솔야생형CC위49.17/66.93％,잡합형CG위37.50/26.77％,돌변형GG위13.33/6.29％,량조비교x2위8.70,0.01＜P＜0.05,등위기인빈솔야생형C위67.92/80.31％,돌변형G위32.08/19.68％,이조비교x2위8.73,P＜0.01.결론:유선암환자조여건강지원자대조조CYP1B1 SNP rs1056827,rs1056836기인형분포빈솔화등위기인빈솔차이유현저성,제시유선암적발생가능여CYP1B1 SNP rs1056827,rs1056836기인다태성구유모충관련.