CAJ | 학술논문

目的：探讨达英-35与雌孕激素序贯治疗青春期功能失调性子宫出血(功血)的疗效及安全性。方法220例青春期功血患者,随机分为A、B两组。A组给予达英-35治疗, B组予雌孕激素序贯疗法(补佳乐+黄体酮)。观察两组疗效。结果达英-35治疗后总有效率为96.9%,雌孕激素序贯疗法有效率为87.8%,达英-35总有效率高于雌孕激素序贯疗法(P<0.05)；达英-35平均控制出血时间(20.4±2.5)h,平均止血时间(35.5±7.6)h,雌孕激素序贯疗法平均控制出血时间(24.3±3.6)h,平均止血时间(41.3±8.7)h。达英-35控制出血时间和止血时间均短于雌孕激素序贯疗法(P<0.05),副反应发生率均较低,差异无统计学意义(P>0.05)。结论达英-35治疗青春期功血能够控制出血量,缩短止血时间。疗效优于雌孕激素。
목적：탐토체영-35여자잉격소서관치료청춘기공능실조성자궁출혈(공혈)적료효급안전성。방법220례청춘기공혈환자,수궤분위A、B량조。A조급여체영-35치료, B조여자잉격소서관요법(보가악+황체동)。관찰량조료효。결과체영-35치료후총유효솔위96.9%,자잉격소서관요법유효솔위87.8%,체영-35총유효솔고우자잉격소서관요법(P<0.05)；체영-35평균공제출혈시간(20.4±2.5)h,평균지혈시간(35.5±7.6)h,자잉격소서관요법평균공제출혈시간(24.3±3.6)h,평균지혈시간(41.3±8.7)h。체영-35공제출혈시간화지혈시간균단우자잉격소서관요법(P<0.05),부반응발생솔균교저,차이무통계학의의(P>0.05)。결론체영-35치료청춘기공혈능구공제출혈량,축단지혈시간。료효우우자잉격소。
Objective To investigate the curative effects and safety of Diane-35 and estrogen and progesterone sequential therapy in the treatment of dysfunctional uterine bleeding in the adolescent at puberty. Methods A total of 220 cases with dysfunctional uterine bleeding in the adolescent at puberty were randomly divided into group A and group B. Group A received Diane-35 treatment, while group B received estrogen and progesterone sequential therapy (progynova and progesterone). The curative effects of the two groups were observed. Results The total effective rate of Diane-35 treatment was 96.9%, and that of estrogen and progesterone sequential therapy was 87.8%. The total effective rate of Diane-35 was higher than that of estrogen and progesterone sequential therapy (P<0.05). In the treatment with Diane-35, the average control hemorrhage time was (20.4±2.5)h, and average hemostasis time was (35.5±7.6)h. In the estrogen and progesterone sequential therapy, average control hemorrhage time was (24.3±3.6)h, and average hemostasis time was (41.3±8.7)h. These times in Diane-35 treatment were shorter than in estrogen and progesterone sequential therapy (P<0.05). The incidences of adverse reactions were low and had no statistically significant difference (P>0.05). Conclusion Diane-35 treatment can reduce bleeding volume and shorten hemostasis time in dysfunctional uterine bleeding in the adolescent at puberty, and its curative effect is better than that of estrogen and progesterone.