CAJ | 학술논문

目的：探讨中枢神经细胞瘤(CNC)的临床病理特点、免疫表型及鉴别诊断，提高对此瘤的认识，避免误诊。方法：分析10例CNC的临床表现、影像学、组织学和免疫表型特点。结果：10例CNC中男性5例，女性5例，年龄9~45岁，中位年龄27.5岁。所有肿瘤均位于脑室系统内。镜下，肿瘤由形态一致的小圆形细胞组成，胞质透明，有核周空晕，呈菊形团状或蜂窝状排列，可见特征性的无核神经元纤维基质岛(神经毡)。免疫组化示10例中枢神经细胞瘤NeuN、Syn(+)，9例NSE(+)，1例GFAP灶性(+)，NF、CgA(-)，Ki-67均<2%。CNC首选手术切除。10例病例随访未见复发。结论：中枢神经细胞瘤是一种伴神经元分化的罕见肿瘤，肿瘤全切术是治疗首选，总体预后良好。免疫组化有助于CNC的诊断及鉴别诊断。
목적：탐토중추신경세포류(CNC)적림상병리특점、면역표형급감별진단，제고대차류적인식，피면오진。방법：분석10례CNC적림상표현、영상학、조직학화면역표형특점。결과：10례CNC중남성5례，녀성5례，년령9~45세，중위년령27.5세。소유종류균위우뇌실계통내。경하，종류유형태일치적소원형세포조성，포질투명，유핵주공훈，정국형단상혹봉와상배렬，가견특정성적무핵신경원섬유기질도(신경전)。면역조화시10례중추신경세포류NeuN、Syn(+)，9례NSE(+)，1례GFAP조성(+)，NF、CgA(-)，Ki-67균<2%。CNC수선수술절제。10례병례수방미견복발。결론：중추신경세포류시일충반신경원분화적한견종류，종류전절술시치료수선，총체예후량호。면역조화유조우CNC적진단급감별진단。
Objective:To study the clinicopathological features,immunophenotype and differential diagnoses of central neurocytoma(CNC) so as to further realize the tumor and avoid misdiagnosis.Method:Clinical manifestations,radiological,histological characteristics and immunophenotype were analyzed in 10 cases of CNC.Result:5 male and 5 female patients,with ages ranging from 9 to 45 years(mean age 27.5 years),and all tumors were located in the ventricular system.Histologically,the tumor were composed of small uniform round cells.These tumor cells with clear cytoplasm and perinuclear halo were arranged in rosettes pattern and honeycomb pattern.The most dominant feature of CNC was the cell-free island of neuropil matrix.Immunohistochemically,10 cases were positive for NeuN and Syn,9 cases were positive for NSE,1 case was partly positive for GFAP,10 cases were negative for NF and CgA.The positive index of Ki-67 was very low in all cases,with less than 2%of the nuclei labeled.Surgical resection was the primary therapy of CNC.No recurrence were seen in the 10 patients followed-up.Conclusion:CNC is a rare tumor with neuronal differentiation.Surgical resection is the primary therapy,CNC has a benign prognosis. in general. Immunohistochemistry is very important for the diagnosis and differential diagnoses of CNC.