CAJ | 학술논문

目的：比较慢性阻塞性肺疾病(COPD)稳定期、急性加重期和健康人群黑素瘤细胞黏附分子(MCAM)含量。方法选取COPD稳定期患者30例，COPD急性加重期患者30例及无COPD疾病的健康体检者(对照组)30例，并通过流式细胞仪检测3组MCAM的含量。结果 COPD稳定期患者的MCAM含量显著高于对照组，COPD急性加重期患者的MCAM含量明显高于COPD稳定期患者及对照组(P<0.05)。结论 COPD急性加重期内皮损伤主要在毛细血管，甚至持续至临床症状消失之后，高水平MCAM提示肺部炎症的存在，预示COPD患者容易急性加重。
목적：비교만성조새성폐질병(COPD)은정기、급성가중기화건강인군흑소류세포점부분자(MCAM)함량。방법선취COPD은정기환자30례，COPD급성가중기환자30례급무COPD질병적건강체검자(대조조)30례，병통과류식세포의검측3조MCAM적함량。결과 COPD은정기환자적MCAM함량현저고우대조조，COPD급성가중기환자적MCAM함량명현고우COPD은정기환자급대조조(P<0.05)。결론 COPD급성가중기내피손상주요재모세혈관，심지지속지림상증상소실지후，고수평MCAM제시폐부염증적존재，예시COPD환자용역급성가중。
Objective To compare MCAM number in stable COPD patients,acute COPD and normal control. Methods MCAM numbers were examined in 30 stable COPD patients,30 patients with acute COPD and 30 healthy non-COPD volunteers (control group)by flow cytometry. Results MCAM number in stable COPD patients was significantly higher than that in control group,MCAM number in patients with acute COPD was significantly higher than that in stable COPD patients and control group respectively (P<0.05). Conclusion Endothelial damage during acute exacerbation of COPD is mainly pulmonary capillary,even continue to the clinical symptoms disappeared.Higher MCAM level suggest the presence of lung inflammation,indicate COPD patients who are susceptible to exacerbation.