CAJ | 학술논문

目的：探讨不同剂量阿司匹林在冠心病行经皮冠状动脉介入术(PCI)后的应用效果。方法选取本院2011年2月~2013年2月行PCI的202例冠心病患者为研究对象，简单抽样法随机分为A、B两组，每组101例，A组给予低剂量阿司匹林(0.1 g/d)，B组给予高剂量阿司匹林(0.3 g/d)。比较两组治疗后6个月随访期内不良脑血管事件发生情况，记录其各项指标的变化情况。结果两组治疗前各项指标比较，差异无统计学意义(P>0.05)；治疗后6、12个月各指标均较治疗前明显降低(P<0.05)；A、B两组治疗后6、12个月血栓烷B2及总胆固醇组间比较，差异无统计学意义(P>0.05)；治疗后6个月，B组三酰甘油(TG)及低密度脂蛋白胆固醇(LDL-C)水平明显低于A组，差异有统计学意义(P<0.05)；治疗后12个月两组各项指标均较治疗6个月后降低，但差异无统计学意义(P>0.05)。治疗后A组不良脑血管事件发生率为13.86%，B组为15.84%，两组差异无统计学意义(字2=0.69，P>0.05)。结论对冠心病患者行PCI后给予低剂量阿司匹林，可有效降低不良脑血管事件发生率，安全性较高，具有临床推广价值。
목적：탐토불동제량아사필림재관심병행경피관상동맥개입술(PCI)후적응용효과。방법선취본원2011년2월~2013년2월행PCI적202례관심병환자위연구대상，간단추양법수궤분위A、B량조，매조101례，A조급여저제량아사필림(0.1 g/d)，B조급여고제량아사필림(0.3 g/d)。비교량조치료후6개월수방기내불량뇌혈관사건발생정황，기록기각항지표적변화정황。결과량조치료전각항지표비교，차이무통계학의의(P>0.05)；치료후6、12개월각지표균교치료전명현강저(P<0.05)；A、B량조치료후6、12개월혈전완B2급총담고순조간비교，차이무통계학의의(P>0.05)；치료후6개월，B조삼선감유(TG)급저밀도지단백담고순(LDL-C)수평명현저우A조，차이유통계학의의(P<0.05)；치료후12개월량조각항지표균교치료6개월후강저，단차이무통계학의의(P>0.05)。치료후A조불량뇌혈관사건발생솔위13.86%，B조위15.84%，량조차이무통계학의의(자2=0.69，P>0.05)。결론대관심병환자행PCI후급여저제량아사필림，가유효강저불량뇌혈관사건발생솔，안전성교고，구유림상추엄개치。
Objective To explore the application effect of different doses of aspirin in coronary heart disease after per-cutaneous coronary intervention (PCI). Methods 202 patients with coronary heart disease,who received PCI in our hos-pital from February 2011 to February 2013 were chosen as the research objects and were randomly divided into group A and group B according to random table method,101 cases in each group.Group A were treated with low dose of as-pirin (0.1 g/d) while group B were treated with high dose of aspirin (0.3 g/d).The occurrence of adverse cerebrovascular events during the 6 month follow-up period were compared between two groups after treatment and its changes were recorded. Results The indexes in two groups before treatment had no significant difference (P>0.05),and all indexes of the two groups six and twelve months after treatment were lower than those before treatment (P<0.05);After six months treatment,TG and LDL-C in group B was lower than that in group A,the difference was significant (P<0.05);The indica-tors of two groups after 12 months treatment were decreased compared with 6 months treatment,but the difference was not significant (P>0.05).The incidence rate of adverse cerebrovascular events after treatment in group A was 13.86%, compared with 15.84%in group B,the difference was not significant (P>0.05). Conclusion Giving a small amount of as-pirin to patients with coronary heart disease patients after PCI can effectively reduce the incidence of adverse cere-brovascular events and has high security.This method has clinical value.