中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2014年
30期
65-67
,共3页
病毒性心肌炎%丙种球蛋白%临床疗效%免疫功能
病毒性心肌炎%丙種毬蛋白%臨床療效%免疫功能
병독성심기염%병충구단백%림상료효%면역공능
Viral myocarditis%Gamma globulin%Clinical efficacy%Immune function
目的：探讨丙种球蛋白辅助治疗小儿病毒性心肌炎的效果及其对患儿免疫功能的改善作用。方法选择本院2012年1月~2014年3月收治的小儿病毒性心肌炎患者76例，随机分为观察组和对照组，各38例，对照组患儿给予常规治疗，观察组患儿在常规治疗的基础上给予丙种球蛋白静脉滴注治疗，治疗4周后评价两组的治疗效果，治疗前后测定患儿T细胞亚群(CD3+、CD4+、CD8+)变化情况。结果对照组治疗总有效率为76.32%，观察组治疗总有效率为92.10%，两组差异有统计学意义(P<0.05)。两组治疗前CD3+、CD4+、CD8+、CD4+/CD8+水平差异无统计学意义(P>0.05)，治疗后观察组CD3+、CD4+、CD8+明显高于对照组，CD4+/CD8+明显低于对照组，差异有统计学意义(P<0.05)。结论丙种球蛋白辅助治疗小儿病毒性心肌炎可提高治疗效果，并且能有效改善患儿的免疫功能，值得临床推广应用。
目的：探討丙種毬蛋白輔助治療小兒病毒性心肌炎的效果及其對患兒免疫功能的改善作用。方法選擇本院2012年1月~2014年3月收治的小兒病毒性心肌炎患者76例，隨機分為觀察組和對照組，各38例，對照組患兒給予常規治療，觀察組患兒在常規治療的基礎上給予丙種毬蛋白靜脈滴註治療，治療4週後評價兩組的治療效果，治療前後測定患兒T細胞亞群(CD3+、CD4+、CD8+)變化情況。結果對照組治療總有效率為76.32%，觀察組治療總有效率為92.10%，兩組差異有統計學意義(P<0.05)。兩組治療前CD3+、CD4+、CD8+、CD4+/CD8+水平差異無統計學意義(P>0.05)，治療後觀察組CD3+、CD4+、CD8+明顯高于對照組，CD4+/CD8+明顯低于對照組，差異有統計學意義(P<0.05)。結論丙種毬蛋白輔助治療小兒病毒性心肌炎可提高治療效果，併且能有效改善患兒的免疫功能，值得臨床推廣應用。
목적：탐토병충구단백보조치료소인병독성심기염적효과급기대환인면역공능적개선작용。방법선택본원2012년1월~2014년3월수치적소인병독성심기염환자76례，수궤분위관찰조화대조조，각38례，대조조환인급여상규치료，관찰조환인재상규치료적기출상급여병충구단백정맥적주치료，치료4주후평개량조적치료효과，치료전후측정환인T세포아군(CD3+、CD4+、CD8+)변화정황。결과대조조치료총유효솔위76.32%，관찰조치료총유효솔위92.10%，량조차이유통계학의의(P<0.05)。량조치료전CD3+、CD4+、CD8+、CD4+/CD8+수평차이무통계학의의(P>0.05)，치료후관찰조CD3+、CD4+、CD8+명현고우대조조，CD4+/CD8+명현저우대조조，차이유통계학의의(P<0.05)。결론병충구단백보조치료소인병독성심기염가제고치료효과，병차능유효개선환인적면역공능，치득림상추엄응용。
Objective To evaluate the effect of gamma globulin in treatment of children with viral myocarditis and its improvement role on immune function. Methods 76 cases of children with viral myocarditis from January 2012 to March 2014 in our hospital were selected and randomly divided into observation group and control group,each of 38 cases,the children in the control group were given with conventional treatment,patients in the observation group were given with intravenous gamma globulin treatment on the basis of conventional therapy.The effects of two groups were e-valuated after 4 weeks of treatment.Before and after treatment,T cell subsets (CD3+,CD4+,CD8+) changes of two groups were measured. Results The total effective rate of control group and observation group was 76.32% and 92.10% respec-tively,the difference was significant (P<0.05).Before treatment,CD3+,CD4+,CD8+,CD4+/CD8+level of two groups showed no significant difference (P>0.05),after treatment,the CD3+,CD4+,CD8+level of observation group was higher than that of con-trol group,CD4+/CD8+ level was lower than that of control group,the differences were significant (P<0.05). Conclusion Gamma globulin adjunctive therapy in children with viral myocarditis can effectively improve the therapeutic effect,and can effectively improve immune function of children,worthy of widely application.
