中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2014年
30期
32-33,36
,共3页
曲美他嗪%冠心病%左心功能不全%治疗机制
麯美他嗪%冠心病%左心功能不全%治療機製
곡미타진%관심병%좌심공능불전%치료궤제
Trimetazidine%Coronary heart disease%Left heart insufficiency%Therapeutic mechanism
目的：探讨曲美他嗪对冠心病左心功能不全患者左心功能的影响。方法选取本院收治的102例冠心病合并左心功能不全患者，随机均分为观察组和对照组。对照组给予洋地黄、β-受体阻滞剂、利尿剂、ACEI/ARB等治疗，观察组在对照组的基础上给予曲美他嗪口服治疗，剂量：20 mg/次，3次/d。比较两组患者左心室收缩末内径、左心室舒张末内径、左室壁运动评分、左室射血分数(LVEF)和NYHA心功能的差异。结果治疗后观察组患者的左心室收缩末内径、左心室舒张末内径、左室壁运动评分和LVEF均显著优于对照组(P<0.05)。观察组患者的NYHA心功能改善率为66.7%，显著高于对照组的41.2%(P<0.05)。观察组患者的恶化率为5.9%，显著低于对照组的23.5%(P<0.05)。结论曲美他嗪治疗冠心病左心功能不全的效果确切，能有效改善患者的左心功能，促进康复，值得临床推广应用。
目的：探討麯美他嗪對冠心病左心功能不全患者左心功能的影響。方法選取本院收治的102例冠心病閤併左心功能不全患者，隨機均分為觀察組和對照組。對照組給予洋地黃、β-受體阻滯劑、利尿劑、ACEI/ARB等治療，觀察組在對照組的基礎上給予麯美他嗪口服治療，劑量：20 mg/次，3次/d。比較兩組患者左心室收縮末內徑、左心室舒張末內徑、左室壁運動評分、左室射血分數(LVEF)和NYHA心功能的差異。結果治療後觀察組患者的左心室收縮末內徑、左心室舒張末內徑、左室壁運動評分和LVEF均顯著優于對照組(P<0.05)。觀察組患者的NYHA心功能改善率為66.7%，顯著高于對照組的41.2%(P<0.05)。觀察組患者的噁化率為5.9%，顯著低于對照組的23.5%(P<0.05)。結論麯美他嗪治療冠心病左心功能不全的效果確切，能有效改善患者的左心功能，促進康複，值得臨床推廣應用。
목적：탐토곡미타진대관심병좌심공능불전환자좌심공능적영향。방법선취본원수치적102례관심병합병좌심공능불전환자，수궤균분위관찰조화대조조。대조조급여양지황、β-수체조체제、이뇨제、ACEI/ARB등치료，관찰조재대조조적기출상급여곡미타진구복치료，제량：20 mg/차，3차/d。비교량조환자좌심실수축말내경、좌심실서장말내경、좌실벽운동평분、좌실사혈분수(LVEF)화NYHA심공능적차이。결과치료후관찰조환자적좌심실수축말내경、좌심실서장말내경、좌실벽운동평분화LVEF균현저우우대조조(P<0.05)。관찰조환자적NYHA심공능개선솔위66.7%，현저고우대조조적41.2%(P<0.05)。관찰조환자적악화솔위5.9%，현저저우대조조적23.5%(P<0.05)。결론곡미타진치료관심병좌심공능불전적효과학절，능유효개선환자적좌심공능，촉진강복，치득림상추엄응용。
Objective To inveatigate the effect of trimetazidine in the treatment of coronary heart disease with left heart insufficiency patients. Methods 102 cases of coronary heart disease with left heart insufficiency patients in our hospital were selected and randomly divided into control group and observation group,the control group was given digitalis,β-blockers,diuretics,ACEI/ARB therapy,the observation group was given trimetazidine oral treatment on the basis of the control group,dosage:20 mg/time,3 times/days.The left heart diameter at the end of shrink and relaxation,motor scores of left ventricular wall and NYHA score of the two groups were compared. Results The left heart diameter at the end of shrink and relaxation,motor scores of left ventricular wall of observation group were significantly better than those of the control group (P<0.05).The NYHA improvement rate of observation group was 66.7%,which was significantly higher than that of the control group (41.2%) (P<0.05).The NYHA degradation rate of observation group was 5.9%,which was significantly lower than 23.5% of the control group (P<0.05). Conclusion Trimetazidine has exact clinical effect on coronary heart disease with left heart insufficiency.It can improve left ventricular function significantly and promote patents recovery.It’s worthy of clinical popularization and application.
