CAJ | 학술논문

心律失常是心脏电活动的频率、节律等活动异常的一种疾病，中药中生物碱、黄酮、皂苷、挥发油、酯类、萜类等多种活性成分可以通过影响 Na ＋、Ca2＋以及 K ＋通道，使动作电位和有效不应期延长，进而对肾上腺素、缺血复灌以及氯化钙等引起的心律失常具有明显的抵抗作用。本文对这几种活性成分的作用机制进行了综述，为进一步研究中药活性成分以及抗心律失常的作用机制提供了坚实的理论基础，为抗心律失常新药的研究开发奠定了基础。
심률실상시심장전활동적빈솔、절률등활동이상적일충질병，중약중생물감、황동、조감、휘발유、지류、첩류등다충활성성분가이통과영향 Na ＋、Ca2＋이급 K ＋통도，사동작전위화유효불응기연장，진이대신상선소、결혈복관이급록화개등인기적심률실상구유명현적저항작용。본문대저궤충활성성분적작용궤제진행료종술，위진일보연구중약활성성분이급항심률실상적작용궤제제공료견실적이론기출，위항심률실상신약적연구개발전정료기출。
Arrhythmias is a type of disease caused by abnormal electrical activity of the heart rate or rhythm.Active ingredients extracted from Chinese herbal medicines such as alkaloids、flavonoids、saponins、volatile oils、esters,terpenes and other active ingredients can im-pact the Na +、Ca2 + and K + channels,so the action potential and effective refractory period can be extended,in that way to treat arrhyth-mias caused by adrenaline,calcium chloride and ischemic reperfusion.This mechanism of these active ingredients were reviewed to pro-vide solid theoretical foundation for further research of anti-arrhythmias drugs.