CAJ | 학술논문

目的：观察苹果多酚（Apple Polyphenols，AP）对小鼠免疫性肝损伤的保护作用。方法：采用卡介苗联合脂多糖制备小鼠免疫性肝损伤模型。研究 AP 对小鼠肝指数和脾指数，血清中谷草转氨酶（Aspartate Transaminase，AST）和谷丙转氨酶（Alanine Transaminase，ALT）活性，血清总蛋白（Total Protein，TP），白蛋白（Albumin，Alb）和白蛋白/球蛋白（A /G）含量的改善作用，同时采用 HE 染色方法观察 AP 对免疫性肝损伤小鼠肝脏病理改变的保护作用。结果：AP 能明显抑制免疫性肝损伤模型小鼠异常升高的肝指数和脾指数，降低血清中 AST 活性，不同程度地升高血清中 TP 和 Alb 的含量，同时对肝组织病理异常变化也有显著的改善作用。结论：AP 对卡介苗联合脂多糖所致的小鼠免疫性肝损伤具有保护作用。
목적：관찰평과다분（Apple Polyphenols，AP）대소서면역성간손상적보호작용。방법：채용잡개묘연합지다당제비소서면역성간손상모형。연구 AP 대소서간지수화비지수，혈청중곡초전안매（Aspartate Transaminase，AST）화곡병전안매（Alanine Transaminase，ALT）활성，혈청총단백（Total Protein，TP），백단백（Albumin，Alb）화백단백/구단백（A /G）함량적개선작용，동시채용 HE 염색방법관찰 AP 대면역성간손상소서간장병리개변적보호작용。결과：AP 능명현억제면역성간손상모형소서이상승고적간지수화비지수，강저혈청중 AST 활성，불동정도지승고혈청중 TP 화 Alb 적함량，동시대간조직병리이상변화야유현저적개선작용。결론：AP 대잡개묘연합지다당소치적소서면역성간손상구유보호작용。
Objective:To observe hepatoprotective role of apple polyphenols (AP,Appjfnol )on immunological liver injury in mice. Methods:An immunological liver injury model in mice was established by intravenous injection of Bacillus Calmette-Guerin (BCG)and lipopolysaccharide (LPS).The liver index and spleen index,the activities of serum aspartate aminotransferase (AST)and alanine ami-notransferase (ALT),the levels of serum total protein (TP),albumin (Alb)and albumin/globulin (A /G)were detected.Histopatho-logic change was also investigated by HE staining.Results:AP inhibited the increases of liver index and spleen index,prevented the in-crease of serum AST activity and the decrease of serum TP and Alb levels.Histopathological abnormalities were also improved after AP administration.Conclusion:AP played a significant hepatoprotective role against BCG and LPS induced immunological liver injury in mice.