CAJ | 학술논문

目的：探讨中医药序贯治疗模式和巩固治疗模式对 III /IV 期胃癌患者总生存期和中位生存期的临床影响。方法：选择于2009年3月至2010年9月在我院治疗的72例经临床诊断为 III /IV 期胃癌的患者，采用随机数字表法将其分为治疗组和对照组各36例，其中给予治疗组患者中医药序贯治疗模式，对照组给予中医药巩固治疗模式，对比患者在接受治疗后总生存和中位生存期情况。结果：治疗组中位 OS 为32个月，明显优于对照组的19个月，2组比较有统计学意义（P ＜0.05），早期服用中药汤剂的患者中位 OS 为24.1个月，明显优于服用较晚患者的14.3个月，比较亦有统计学意义（P ＜0.05）；治疗组的 MST 为17.2个月，明显优于对照组的6.9个月，2组比较亦有统计学意义（P ＜0.05）。结论：虽中西医结合治疗胃癌可有效延长患者生存期，但中医药序贯治疗模式较巩固治疗模式而言，能更加有较的延长患者生存期，值得进一步推广应用。
목적：탐토중의약서관치료모식화공고치료모식대 III /IV 기위암환자총생존기화중위생존기적림상영향。방법：선택우2009년3월지2010년9월재아원치료적72례경림상진단위 III /IV 기위암적환자，채용수궤수자표법장기분위치료조화대조조각36례，기중급여치료조환자중의약서관치료모식，대조조급여중의약공고치료모식，대비환자재접수치료후총생존화중위생존기정황。결과：치료조중위 OS 위32개월，명현우우대조조적19개월，2조비교유통계학의의（P ＜0.05），조기복용중약탕제적환자중위 OS 위24.1개월，명현우우복용교만환자적14.3개월，비교역유통계학의의（P ＜0.05）；치료조적 MST 위17.2개월，명현우우대조조적6.9개월，2조비교역유통계학의의（P ＜0.05）。결론：수중서의결합치료위암가유효연장환자생존기，단중의약서관치료모식교공고치료모식이언，능경가유교적연장환자생존기，치득진일보추엄응용。
Objective:To investigate the effect of Chinese medicine sequential treatment patterns and consolidation therapy patterns on overall survival time and median survival time of patients with stage III /IV gastric cancer.Methods:Seventy two patients who were di-agnosed as stage III /IV gastric cancer and received treatment in March 2009 to September 2010 in our hospital were randomly divided in-to treatment group (n =36)and control group (n =36).Patients in the treatment group were given sequential TCM treatment and pa-tients in the control group received consolidation TCMtherapy.The overall survival after treatment and median survival situation were ob-served.Results:The median OS of the treatment group was 32 months,which was significantly better than the 19 months of the control group (P <0.05);the median OS of patients who took decoction in early stage was 24.1 months,which was significantly better than the 14.3 months of those took decoction later,and there was statistically significant difference (P <0.05);MST of treatment group was 17. 2 months,which was significantly better than the 6.9 months in the control group,and the difference was also statistically significant (P<0.05).Conclusion:Although the combination therapy may prolong survival in gastric cancer patients,but sequential treatment of can better prolong the survival of patients,and therefore it is worthy of further applications.