世界中医药
世界中醫藥
세계중의약
WORLD CHINESE MEDICINE
2014年
9期
1186-1189
,共4页
王胜圣%王晓岩%回春%周杰
王勝聖%王曉巖%迴春%週傑
왕성골%왕효암%회춘%주걸
中西医结合%冷哮%热哮%急性发作期%临床观察
中西醫結閤%冷哮%熱哮%急性髮作期%臨床觀察
중서의결합%랭효%열효%급성발작기%림상관찰
Integrated traditional Chinese and Western medicine%Cold wheezing%Heat wheezing%Acute exacerbation%Clinical Observation
目的：评价哮喘急性发作期中医综合治疗方案的疗效和安全性，并总结出优势和特色。方法：采用随机、对照、多中心、大样本的方法进行临床试验研究360例，分冷哮、热哮两个证候，其中冷哮180例，试验组90例，对照组90例；热哮180例，试验组90例，对照组90例，试验组分别应用“喘嗽宁片”“喘息康颗粒”，并加外用咳喘膏贴剂，根据实际需求适当加用万托林吸入；对照组采用常规西药治疗方案。试验结束后进行哮喘疾病综合疗效、中医证候疗效评价，万托林使用天数及次数，肺功能、ECP、PEF 变异率指标评价。治疗期疗程为10 d。结果：1）冷哮、热哮2组在疾病疗效愈显率及总有效率方面试验组均较对照组好，但差异无统计学意义，综合试验组与综合对照组愈显率比较差异有统计学意义，P ＜0.05；2）冷哮、热哮组、综合试验组中医证候疗效愈显率及总有效率组间差异无统计学意义，P ＞0.05，但试验组痊愈及显效的例数明显多于对照组；3）冷哮、热哮2组在万托林使用天数和次数均少于对照组，但组间比较无统计学意义；4）冷哮试验组 FEV1％、FEV1、PEFR、FVC 治疗前后有明显差异，对照组 FEV1％、FEV1、PEFR 治疗前后有明显统计学意义，热哮试验组 FEV1％治疗前后，对照组 FEV1％、PEFR、FVC、FEV1治疗前后有明显统计学意义，2组组间比较无统计学意义（P ＞0.05）。结论：中西医结合治疗哮喘急性发作期（冷哮、热哮）疗效显著且安全可靠。
目的：評價哮喘急性髮作期中醫綜閤治療方案的療效和安全性，併總結齣優勢和特色。方法：採用隨機、對照、多中心、大樣本的方法進行臨床試驗研究360例，分冷哮、熱哮兩箇證候，其中冷哮180例，試驗組90例，對照組90例；熱哮180例，試驗組90例，對照組90例，試驗組分彆應用“喘嗽寧片”“喘息康顆粒”，併加外用咳喘膏貼劑，根據實際需求適噹加用萬託林吸入；對照組採用常規西藥治療方案。試驗結束後進行哮喘疾病綜閤療效、中醫證候療效評價，萬託林使用天數及次數，肺功能、ECP、PEF 變異率指標評價。治療期療程為10 d。結果：1）冷哮、熱哮2組在疾病療效愈顯率及總有效率方麵試驗組均較對照組好，但差異無統計學意義，綜閤試驗組與綜閤對照組愈顯率比較差異有統計學意義，P ＜0.05；2）冷哮、熱哮組、綜閤試驗組中醫證候療效愈顯率及總有效率組間差異無統計學意義，P ＞0.05，但試驗組痊愈及顯效的例數明顯多于對照組；3）冷哮、熱哮2組在萬託林使用天數和次數均少于對照組，但組間比較無統計學意義；4）冷哮試驗組 FEV1％、FEV1、PEFR、FVC 治療前後有明顯差異，對照組 FEV1％、FEV1、PEFR 治療前後有明顯統計學意義，熱哮試驗組 FEV1％治療前後，對照組 FEV1％、PEFR、FVC、FEV1治療前後有明顯統計學意義，2組組間比較無統計學意義（P ＞0.05）。結論：中西醫結閤治療哮喘急性髮作期（冷哮、熱哮）療效顯著且安全可靠。
목적：평개효천급성발작기중의종합치료방안적료효화안전성，병총결출우세화특색。방법：채용수궤、대조、다중심、대양본적방법진행림상시험연구360례，분랭효、열효량개증후，기중랭효180례，시험조90례，대조조90례；열효180례，시험조90례，대조조90례，시험조분별응용“천수저편”“천식강과립”，병가외용해천고첩제，근거실제수구괄당가용만탁림흡입；대조조채용상규서약치료방안。시험결속후진행효천질병종합료효、중의증후료효평개，만탁림사용천수급차수，폐공능、ECP、PEF 변이솔지표평개。치료기료정위10 d。결과：1）랭효、열효2조재질병료효유현솔급총유효솔방면시험조균교대조조호，단차이무통계학의의，종합시험조여종합대조조유현솔비교차이유통계학의의，P ＜0.05；2）랭효、열효조、종합시험조중의증후료효유현솔급총유효솔조간차이무통계학의의，P ＞0.05，단시험조전유급현효적례수명현다우대조조；3）랭효、열효2조재만탁림사용천수화차수균소우대조조，단조간비교무통계학의의；4）랭효시험조 FEV1％、FEV1、PEFR、FVC 치료전후유명현차이，대조조 FEV1％、FEV1、PEFR 치료전후유명현통계학의의，열효시험조 FEV1％치료전후，대조조 FEV1％、PEFR、FVC、FEV1치료전후유명현통계학의의，2조조간비교무통계학의의（P ＞0.05）。결론：중서의결합치료효천급성발작기（랭효、열효）료효현저차안전가고。
Objective:To evaluate effect and safety of comprehensive treatment protocol of Chinese medicine for acute exacerbation of asthma,and to sum up its advantages and characteristics.Methods:A randomized,controlled,multi-center clinical trial was conducted with large samples.The recruited 360 patients included 180 cases of heat wheezing syndrome and 180 cases of cold wheezing syndrome. Heat wheezing patients were divided into treatment group (n =90)and control group (n =90);Cold wheezing patients were also divided into treatment group (n =90)and control group (n =90).Patients in both treatment groups were applied “Kesouning tablets”,“Chua-nkangxi granules”and external administration of Xiaoke ointment patch,as well as Ventolin inhalation depending on situations;both control groups gave patients conventional western medicine.After treatment,patients were given evaluations on comprehensive effect of asthma,TCMsyndromes,Ventolin application days and times,pulmonary function,ECP,PEF variation rate index.Course of the treat-ment period was 10 days.Results:1)Both treatment groups of cold wheezing and heat wheezing patients showed better results in re-markably effective rate and total effective rate compared with their own control groups,but there was no statistically significant differ-ence.While taking treatment groups and control groups as two big groups,the remarkably effective rate and total effective rate of treat-ment group showed significant differences from that of the control group (P <0.05);2)Remarkably effective rate and total effective rate from the aspect of Chinese medicine syndrome showed no significant differences between the treatment groups and control groups no mat-ter compared among cold wheezing patients,heat wheezing patients or all the patients (P >0.05).However,there were more remark-ably effective and total effective cases in the treatment groups;3)Ventolin usage were less in both treatment groups compared with their own control groups.4)ECP,PEF mutation rate,pulmonary function all showed significant improvement after treatment.Conclusion:Integrated Chinese and Western medicine shows reliable effectiveness and safety to treat acute exacerbation of asthma (wheezing cold, heat wheezing).
