CAJ | 학술논문

目的：评价解郁安神定志汤合用帕罗西汀治疗抑郁症的临床疗效、安全性。方法：本研究通过组内治疗前后和对照组的比较临床研究，对比抑郁症患者的抑郁、焦虑状态改变。结果：1）2组 HAMD、HAMA 的总分显著降低，治疗后与治疗前比较有统计学意义（P ＜0.05）。解郁安神定志汤合用帕罗西汀组治疗有效率达97.4％，对照组有效率达89.7％。2）解郁安神定志汤合用帕罗西汀组出现不良反应的有7例（17.9％），对照组出现不良反应的有27例（69.2％），2组有统计学意义（P ＜0.01）。结论：解郁安神定志汤合用帕罗西汀治疗抑郁症安全有效，通过治疗既能减轻患者的抑郁程度，又能改善伴随的焦虑状态，同时引起的不良反应远远低于单纯西药治疗。
목적：평개해욱안신정지탕합용파라서정치료억욱증적림상료효、안전성。방법：본연구통과조내치료전후화대조조적비교림상연구，대비억욱증환자적억욱、초필상태개변。결과：1）2조 HAMD、HAMA 적총분현저강저，치료후여치료전비교유통계학의의（P ＜0.05）。해욱안신정지탕합용파라서정조치료유효솔체97.4％，대조조유효솔체89.7％。2）해욱안신정지탕합용파라서정조출현불량반응적유7례（17.9％），대조조출현불량반응적유27례（69.2％），2조유통계학의의（P ＜0.01）。결론：해욱안신정지탕합용파라서정치료억욱증안전유효，통과치료기능감경환자적억욱정도，우능개선반수적초필상태，동시인기적불량반응원원저우단순서약치료。
Objective:The clinical study of Jieyu Anshen Dingzhi decoction combined with western medicine was conducted so as to e-valuate the efficacy and safety on depression and anxiety state.Methods:To compare the depression and anxiety state in the two groups before and after treatment ,and investigate the differences between the two groups.Results:1)After treatment,the score of HAMD and HAMA were significantly reduced (P <0.05).The effective rate in the group applying Jieyu Anshen Dingzhi decoction combined with Paroxetine reached to 97.4%.And the effective rate was 89.7% in the control group.2)The incident rate of adverse reaction in the group of Jieyu Anshen Dingzhi decoction combined with Paroxetine was 17.9%,while that of the control group was 69.2%.There was significant difference between the two groups (P <0.01).Conclusion:Jieyu Anshen Dingzhi decoction combined with western medicine has irrefutable clinical efficacy on depression,which is safe and effective treatment.And the adverse reaction is way less than Paroxe-tine.