CAJ | 학술논문

目的：研究原发性肺癌患者中医证型分布规律及其与化疗及靶向治疗之间的相关性，为肺癌中医证型研究与临床应用提供理论支持。方法：采用统一的中医证型调查表对上海中医药大学附属龙华医院肿瘤科和上海市肺科医院中医科的肺癌患者进行中医辨证，分析肺癌中医证型分布规律，另对病例中的上海市肺科医院患者分析，探讨肺癌不同中医证型分布规律与化疗及靶向之间的相关性。结果：淤原发性肺癌患者中医证型以肺阴虚证、肺气虚证、瘀阻肺络证、脾气虚证、肺阴虚火旺证为主；于肺癌中医证型演变与不同治疗方法存在一定的相关性，其中靶向治疗对肺阴虚证的影响较为显著（P<0.05），主要表现为靶向治疗后肺阴虚证明显增多。结论：淤肺癌中医证型分布具有一定规律，以肺阴虚证、肺气虚证、瘀阻肺络证、脾气虚证、肺阴虚火旺证为主；于肺癌中医证型演变与靶向之间存在一定的相关性，主要表现为靶向治疗后肺阴虚证明显增多。
목적：연구원발성폐암환자중의증형분포규률급기여화료급파향치료지간적상관성，위폐암중의증형연구여림상응용제공이론지지。방법：채용통일적중의증형조사표대상해중의약대학부속룡화의원종류과화상해시폐과의원중의과적폐암환자진행중의변증，분석폐암중의증형분포규률，령대병례중적상해시폐과의원환자분석，탐토폐암불동중의증형분포규률여화료급파향지간적상관성。결과：어원발성폐암환자중의증형이폐음허증、폐기허증、어조폐락증、비기허증、폐음허화왕증위주；우폐암중의증형연변여불동치료방법존재일정적상관성，기중파향치료대폐음허증적영향교위현저（P<0.05），주요표현위파향치료후폐음허증명현증다。결론：어폐암중의증형분포구유일정규률，이폐음허증、폐기허증、어조폐락증、비기허증、폐음허화왕증위주；우폐암중의증형연변여파향지간존재일정적상관성，주요표현위파향치료후폐음허증명현증다。
This article was aimed to study the relevance between traditional Chinese medicine ( TCM ) syndromes and the treatment of chemotherapy and targeted therapy , in order to provide theoretical support for TCM syndromes of lung cancer in the clinical application . Uniform TCM syndromes questionnaire was used in the TCM syndrome differentiation among lung cancer patients from the Oncology Department of Longhua Hospital, Shanghai University of Traditional Chinese Medicine and TCM Department of Shanghai Pulmonary Hospital. The analysis was made on correlation between distribution rules of TCM syndromes and chemotherapy and targeted therapy . The results showed that among primary lung cancer patients , the most TCM syndromes were syndrome of lung-yin deficiency , lung-q i deficiency , blood stasis in lung collaterals , spleen-q i deficiency , lung-yin deficiency with fire excess . There were certain correlation in TCM syndromes and different TCM therapeutic methods , in which targeted therapy had great significant effect on syndrome of lung-yin deficiency ( P < 0 . 05 ) , after targeted therapy syndrome of lung-yin deficiency increased obviously . It was concluded that there were some regulations in TCM syndromes of lung cancer which take syndrome of lung-yin deficiency, lung-qi deficiency, blood stasis in lung collaterals, spleen-qi deficiency, lung-yin deficiency with fire excess. There were certain correlation in TCM syndromes and different TCM therapeutic methods , after targeted therapy syndrome of lung-yin deficiency increased obviously .