CAJ | 학술논문

目的：探讨电针对链脲佐菌素诱导的大鼠糖尿病周围神经病（ DPN）模型坐骨神经中神经调节蛋白1（Nrg1）和表皮生长因子受体2（ErbB2）表达的影响。方法：大鼠随机分为正常组、模型组、普通针刺组、电针组。链脲佐菌素腹腔注射制备实验DPN大鼠模型，造模后14天检测各组血糖及坐骨神经传导速度，实时荧光定量PCR检测坐骨神经Nrg1和ErbB2 mRNA表达。结果：与正常组比较，模型组、电针组和普通针刺组血糖显著增高（P＜0．01）。与模型组比较，电针组和普通针刺组神经传导速度显著增高（P＜0．01），坐骨神经Nrg1和ErbB2 mRNA表达显著上调（P＜0．01），其中电针组治疗效果优于普通针刺组（P＜0．05）。结论：电针可通过上调糖尿病周围神经病坐骨神经Nrg1和ErbB2 mRNA表达，促进施万细胞生存，改善糖尿病周围神经病坐骨神经功能。
목적：탐토전침대련뇨좌균소유도적대서당뇨병주위신경병（ DPN）모형좌골신경중신경조절단백1（Nrg1）화표피생장인자수체2（ErbB2）표체적영향。방법：대서수궤분위정상조、모형조、보통침자조、전침조。련뇨좌균소복강주사제비실험DPN대서모형，조모후14천검측각조혈당급좌골신경전도속도，실시형광정량PCR검측좌골신경Nrg1화ErbB2 mRNA표체。결과：여정상조비교，모형조、전침조화보통침자조혈당현저증고（P＜0．01）。여모형조비교，전침조화보통침자조신경전도속도현저증고（P＜0．01），좌골신경Nrg1화ErbB2 mRNA표체현저상조（P＜0．01），기중전침조치료효과우우보통침자조（P＜0．05）。결론：전침가통과상조당뇨병주위신경병좌골신경Nrg1화ErbB2 mRNA표체，촉진시만세포생존，개선당뇨병주위신경병좌골신경공능。
Objective:To investigate the effects of electroacupuncture on the expression of Nrg1 and ErbB2 in the sciatic nerve of rats with diabetic peripheral neuropathy ( DPN) .Methods:The rats were randomly divided into a normal group,a model group,a common acupuncture group and an electroacupuncture group.The rat mod-els with diabetic peripheral neuropathy were established by streptozotocin peritoneal injection method.14 days after modeling, the blood sugar and conduction velocity of sciatic nerve were measured,and the mRNA expres-sions of Nrg1 and ErbB2 in the sciatic nerve were detected by RT-PCR.Results:14 days after modeling,com-pared with the normal group, the blood sugar of model group, acupuncture group and electroacupuncture group was increased (P<0.01).Compared with the model group, the conduction velocity of sciatic nerve was in-creased in common acupuncture group and electroacupuncture group ( P<0.01 ) , and mRNA expressions of Nrg1 and ErbB2 in sciatic nerve were increased ( P<0.01) .While it was improved more obviously in the elec-troacupuncture group than that in the common acupuncture group ( P<0.05) .Conclusion:Electroacupuncture could promote the nerve functional recovery of diabetic peripheral neuropathy by elevating Nrg1 and ErbB2 in sciatic nerve, and promote Schwann cells survival.