CAJ | 학술논문

免疫赦免的丢失是原发性瘢痕性脱发和斑秃的主要机制之一,免疫赦免指特定的组织和解剖结构,通过获得免疫效应细胞在外来抗原入侵时保护自己免受免疫攻击.因为具备独特的免疫和激素环境,生长期毛囊的毛球和毛囊外根鞘的隆突区被认为具备“相对免疫赦免”的能力.局部免疫赦免的丢失导致毛囊自身抗原的免疫反应,可以引起斑秃、原发性瘢痕性脱发等疾病发生.恢复免疫赦免有助于治疗这些疾病.
면역사면적주실시원발성반흔성탈발화반독적주요궤제지일,면역사면지특정적조직화해부결구,통과획득면역효응세포재외래항원입침시보호자기면수면역공격.인위구비독특적면역화격소배경,생장기모낭적모구화모낭외근초적륭돌구피인위구비“상대면역사면”적능력.국부면역사면적주실도치모낭자신항원적면역반응,가이인기반독、원발성반흔성탈발등질병발생.회복면역사면유조우치료저사질병.
Immune privilege refers to specific tissues and anatomical structures,by obtaining immune effector cells,provides protection to vital tissues or cells of the body when foreign antigens are introduced into these sites.The bulb and bulge in the out root sheath of anagen hair follicles are considered to be sites of " relative immune privilege" because of their distinct immune and hormonal microenvironment.The collapse of immune privilege may lead to immune reactions against autoantigens in hair follicles,and cause alopecia areata,primary cicatricial alopecia and other autoimmune diseases.Rebuilding immune privilege may benefit the treatment of these entities.