CAJ | 학술논문

小鼠是最常用的哺乳动物模式生物，其毛色有白色、灰色、黄色、黑色等，是典型的孟德尔遗传性状。但在本科遗传学教学中，一般只在介绍隐性致死基因的时候才提到小鼠毛色遗传的例子。作者深入挖掘和整理了小鼠毛色遗传的分子机制，并把这个例子贯穿于讲解孟德尔遗传以及介绍分子遗传学的基因结构、基因功能、基因调控、基因互作、基因的表观遗传学修饰和数量性状遗传等，尝试用同一个案例贯穿本科遗传学教学，培养学生建立由表及里的系统分析能力，既凸显遗传学研究的前沿性和完整性，又吸引了学生的注意力，激发了学生的学习兴趣，收到了很好的教学效果。
소서시최상용적포유동물모식생물，기모색유백색、회색、황색、흑색등，시전형적맹덕이유전성상。단재본과유전학교학중，일반지재개소은성치사기인적시후재제도소서모색유전적례자。작자심입알굴화정리료소서모색유전적분자궤제，병파저개례자관천우강해맹덕이유전이급개소분자유전학적기인결구、기인공능、기인조공、기인호작、기인적표관유전학수식화수량성상유전등，상시용동일개안례관천본과유전학교학，배양학생건립유표급리적계통분석능력，기철현유전학연구적전연성화완정성，우흡인료학생적주의력，격발료학생적학습흥취，수도료흔호적교학효과。
Mice are the most commonly used mammalian model. The coat colors of mice are typical Mendelian traits, which have various colors such as white, black, yellow and agouti. The inheritance of mouse coat color is usually stated as an example only in teaching the knowledge of recessive lethal alleles. After searched the related literatures and summarized the molecular mechanisms of mouse coat color inheritance, we further expanded the application of this example into the introduc-tion of the basic concepts of alleles and Mendelian laws, demonstration of the gene structure and function, regulation of gene expression, gene interaction, epigenetic modification, quantitative genetics, as well as evolutionary genetics. By running this example through the whole genetics-teaching lectures, we help the student to form a systemic and developmental view of ge-netic analysis. At the same time, this teaching approach not only highlights the advancement and integrity of genetics, but also results in a good teaching effect on inspiring the students’ interest and attracting students’ attention.