CAJ | 학술논문

目的：考察人免疫球蛋白联合阿糖腺苷和甲强龙治疗 EB 病毒感染的临床疗效。方法将100例 EB 病毒感染患者随机分为研究组和对照组，每组各50例。对照组给予阿糖腺苷和甲强龙治疗，研究组给予人免疫球蛋白联合单磷酸阿糖腺苷和甲强龙治疗。比较两组的病毒转阴率和治疗前后的症状总积分。结果研究组病毒转阴率为82.0%，对照组为50.0%，两组存在统计学差异（P <0.01）；治疗前研究组和对照组的症状总积分分别为（12.3±9.4）和（10.9±7.0）分，两组无统计学差异（P >0.05），治疗后研究组和对照组的症状总积分分别为（3.9±3.3）和（6.1±4.8）分，两组存在统计学差异（P <0.05）。结论人免疫球蛋白联合阿糖腺苷和甲强龙治疗 EB 病毒感染安全、有效，具有临床应用价值。
목적：고찰인면역구단백연합아당선감화갑강룡치료 EB 병독감염적림상료효。방법장100례 EB 병독감염환자수궤분위연구조화대조조，매조각50례。대조조급여아당선감화갑강룡치료，연구조급여인면역구단백연합단린산아당선감화갑강룡치료。비교량조적병독전음솔화치료전후적증상총적분。결과연구조병독전음솔위82.0%，대조조위50.0%，량조존재통계학차이（P <0.01）；치료전연구조화대조조적증상총적분분별위（12.3±9.4）화（10.9±7.0）분，량조무통계학차이（P >0.05），치료후연구조화대조조적증상총적분분별위（3.9±3.3）화（6.1±4.8）분，량조존재통계학차이（P <0.05）。결론인면역구단백연합아당선감화갑강룡치료 EB 병독감염안전、유효，구유림상응용개치。
Objective To observe the effects of immunoglobulin treatment combined with Vidarabine(Ara-A)and Sou-Medrol (Sou-M)on EB virus infection. Methods Total 100 patients with EB infection were selected and divided into two groups,i. e. ,control group and study group,50 ones in each group. For the control group,vidarabine monophosphate and prednisolone were administered, while human immunoglobulin with Are-A and prednisolone were administered together for the study group. The negative transformation rate of virus and the total symptom scores were compared before and after the treatment of the two groups and between both groups. Results The negative transformation rate of virus was 82. 0% in the study group and was 50. 0% in the control group. The different between the two groups was significant(P < 0. 01). Before the treatment,the total symptom score of both groups were 12. 3 ± 9. 4 and 10. 9 ± 7. 0,respectively,with no significant difference between them(P > 0. 05);but after the treatment,the total symptoms scores were 3. 9 ± 3. 3 and 6. 1 ± 4. 8,respectively,and there was a significant difference between both groups( P < 0. 05). Conclusion The application of human immunoglobulin with Ara-A and prednisolone to treatment of EB virus infection is safe and effective,and is of value in clinical use.