CAJ | 학술논문

目的：研究口腔白斑念珠菌感染的临床和病理学特征。方法：利用过碘酸雪夫染色诊断念珠菌感染，回顾性分析448例白斑患者的活检组织中念珠菌感染率，并分析年龄、性别、白斑病损部位、白斑上皮异常增生等因素与感染的关系。结果：白斑组织中念珠菌的感染率14．1％。念珠菌性白斑比普通型白斑的上皮异常增生发生率更高（57．1％vs．33．8％）。回归分析显示＞60岁的老年患者、舌部白斑和上皮异常增生是念珠菌易感因素。结论：念珠菌感染和上皮异常增生密切相关。伴有上皮异常增生的舌部白斑的老年患者更易感染念珠菌。
목적：연구구강백반념주균감염적림상화병이학특정。방법：이용과전산설부염색진단념주균감염，회고성분석448례백반환자적활검조직중념주균감염솔，병분석년령、성별、백반병손부위、백반상피이상증생등인소여감염적관계。결과：백반조직중념주균적감염솔14．1％。념주균성백반비보통형백반적상피이상증생발생솔경고（57．1％vs．33．8％）。회귀분석현시＞60세적노년환자、설부백반화상피이상증생시념주균역감인소。결론：념주균감염화상피이상증생밀절상관。반유상피이상증생적설부백반적노년환자경역감염념주균。
Objective:To study the clinical and pathological features of Candida infection in oral leukoplakia. Method:Candidal hyphae were detected with periodic acid-Schiff staining of the biopsy samples from a retrospective series of 448 cases of patients with oral leukoplakia,and analyze the relationship between age,sex,location,and epithelial dysplasia and infection. Result:Of them,63 patients (16.4 %) with oral leukoplakia were infected by Candida. Candidal leukoplakia was highly associated with dysplasia compared to common type (57.1 % vs. 33.8 %). Regression analysis showed that >60 years,tongue and dysplasia are predisposing factors. Conclusion:Candida infection correlated with dysplasia. Elderly pa-tients with tongue leukoplakia with dysplasia had much higher risk of candidal infection.