临床口腔医学杂志
臨床口腔醫學雜誌
림상구강의학잡지
JOURNAL OF CLINICAL STOMATOLOGY
2014年
10期
619-621,622
,共4页
口腔%鳞癌%中晚期%术前化疗%术前放疗
口腔%鱗癌%中晚期%術前化療%術前放療
구강%린암%중만기%술전화료%술전방료
oral and maxillofacial region%squamous cell carcinoma%middle-late%preoperative induced chemothera-py%preoperative radiotherapy
目的：探讨术前化疗、放疗联合手术综合方案治疗口腔中晚期鳞癌的临床效果。方法：对经病理确诊的104例口腔中晚期鳞癌患者行术前化疗、放疗1周期，再行联合根治手术。并对患者术后局部复发率、远处转移率、生存率、生活质量、张口度及钛板排斥、感染、断裂等情况进行临床观察。结果：口腔中晚期鳞癌术前化疗、放疗总有效率达98．08％，手术切除率达100％，术后不良反应轻，局部复发率1．92％（2例），远处转移率2．88％（3例），出现钛板排斥、感染反应导致张口受限2．88％（3例）。术后患者5年生存率91．35％（95例）。结论：术前化疗、放疗产生积极的抗肿瘤作用，取得满意的临床效果，为进一步手术治疗提供了良好的基础。术前化疗、放疗联合手术综合方案治疗中晚期口腔鳞癌，可提高患者远期生存率，手术切除率，术后不良反应轻。
目的：探討術前化療、放療聯閤手術綜閤方案治療口腔中晚期鱗癌的臨床效果。方法：對經病理確診的104例口腔中晚期鱗癌患者行術前化療、放療1週期，再行聯閤根治手術。併對患者術後跼部複髮率、遠處轉移率、生存率、生活質量、張口度及鈦闆排斥、感染、斷裂等情況進行臨床觀察。結果：口腔中晚期鱗癌術前化療、放療總有效率達98．08％，手術切除率達100％，術後不良反應輕，跼部複髮率1．92％（2例），遠處轉移率2．88％（3例），齣現鈦闆排斥、感染反應導緻張口受限2．88％（3例）。術後患者5年生存率91．35％（95例）。結論：術前化療、放療產生積極的抗腫瘤作用，取得滿意的臨床效果，為進一步手術治療提供瞭良好的基礎。術前化療、放療聯閤手術綜閤方案治療中晚期口腔鱗癌，可提高患者遠期生存率，手術切除率，術後不良反應輕。
목적：탐토술전화료、방료연합수술종합방안치료구강중만기린암적림상효과。방법：대경병리학진적104례구강중만기린암환자행술전화료、방료1주기，재행연합근치수술。병대환자술후국부복발솔、원처전이솔、생존솔、생활질량、장구도급태판배척、감염、단렬등정황진행림상관찰。결과：구강중만기린암술전화료、방료총유효솔체98．08％，수술절제솔체100％，술후불량반응경，국부복발솔1．92％（2례），원처전이솔2．88％（3례），출현태판배척、감염반응도치장구수한2．88％（3례）。술후환자5년생존솔91．35％（95례）。결론：술전화료、방료산생적겁적항종류작용，취득만의적림상효과，위진일보수술치료제공료량호적기출。술전화료、방료연합수술종합방안치료중만기구강린암，가제고환자원기생존솔，수술절제솔，술후불량반응경。
Objective:To investigate the clinical effect of the integrated program of preoperative chemotherapy ,ra-diotherapy combined with surgery to cure middle-late squamous cell carcinoma of oral. Method:A total of 104 biopsy con-firmed cases from our hospital,were included in this research. The patients needed to accept preoperative chemotherapy and the radiotherapy for 1 cycle. And then the combined radical operations started. The clinical effect was researched in aspects of local recurrence rate,distant metastasis rate,survival rate,quality of life,mouth opening,and titanium rejection,infection, fracture and so on. Result:The effective rate of preoperative chemotherapy and radiotherapy to treat middle-late squamous cell carcinoma of oral was 98.08%.The rate of surgery resection after preoperative induced chemotherapy and preoperative radiotherapy was 100%with less postoperative adverse reactions. The local recurrence rate was only 1.92 %(2 cases). The distant metastasis rate was only 2.88 %(3 cases). The rate of titanium rejection and infection reaction that leads to restric-tion of mouth opening was only 2.88 %(3 cases). The 5-year survival rate after operation was 91.35 %(95 cases). Cnclu-sion:Preoperative chemotherapy and radiotherapy have a good clinical effect in positive anti-tumor,providing a good founda-tion for further surgical treatment.The integrated program of preoperative induced chemotherapy,preoperative radiotherapy combined with surgery can raise the long-term survival rate,surgery resection rate and has little adverse reactions.It would be worthy of disseminating and applying for the comprehensive treatment of middle-late squamous cell carcinoma of oral and maxillofacial region.
