CAJ | 학술논문

目的：探索羟基磷灰石/凝胶支架（HAP-GEL）复合成骨细胞在兔颅骨缺损中的修复效果。方法：将HAP-GEL复合物与成骨细胞联合培养，制备兔颅顶骨骨缺损模型，根据植入材料分为3组，分别为HAP-GEL复合成骨细胞、HAP-GEL支架与空白对照。于术后12周通过大体标本观察、X线与CT分析骨缺损修复情况。结果：术后12周影像学评估，空白对照组骨缺损均为明显透射影；HAP-GEL支架复合成骨细胞与HAP-GEL支架组均为低密度影，缺损的边缘略显模糊。结论：HAP-GEL复合成骨细胞修复兔颅骨缺损，可取得较好的修复效果。
목적：탐색간기린회석/응효지가（HAP-GEL）복합성골세포재토로골결손중적수복효과。방법：장HAP-GEL복합물여성골세포연합배양，제비토로정골골결손모형，근거식입재료분위3조，분별위HAP-GEL복합성골세포、HAP-GEL지가여공백대조。우술후12주통과대체표본관찰、X선여CT분석골결손수복정황。결과：술후12주영상학평고，공백대조조골결손균위명현투사영；HAP-GEL지가복합성골세포여HAP-GEL지가조균위저밀도영，결손적변연략현모호。결론：HAP-GEL복합성골세포수복토로골결손，가취득교호적수복효과。
Objective:To investigate the ability of HAP-GEL/osteoblasts scaffolds to repair cranial bone defect. Method:HAP-GEL and osteoblasts were co-culture.The rabbits cranial parietal bone defect models were prepared.Respec-tively HAP-GEL/osteoblasts scaffolds and HAP-GEL scaffolds were implanted into the cranial bone defects area. After 12 weeks,the result was evaluated by gross inspection and imaging evaluation. Result:Blank defects were significantly ridiolu-cent area in the imaging of 12 weeks,HAP-GEL/osteoblasts and HAP-GEL scaffolds were low density area. Conclusion:The engineering bone constructed by HAP-GEL scaffolds and osteoblasts scaffold can be applied to the repair of bone defect in rabbit.