临床肝胆病杂志
臨床肝膽病雜誌
림상간담병잡지
CHINESE JOURNAL OF CLINICAL HEPATOLOGY
2014年
10期
1050-1052
,共3页
肝炎,乙型,慢性%肝硬化%自我遵嘱服药%恩替卡韦
肝炎,乙型,慢性%肝硬化%自我遵囑服藥%恩替卡韋
간염,을형,만성%간경화%자아준촉복약%은체잡위
hepatitis B,chronic%liver cirrhosis%self administration%entecavir
目的：探讨加强自我管理对乙型肝炎肝硬化失代偿期患者恩替卡韦抗病毒治疗的依从性及疗效的影响。方法选取2010年1月-2012年1月在福建医科大学附属泉州市第一医院住院使用恩替卡韦抗病毒治疗的乙型肝炎肝硬化失代偿期患者120例，随机分为对照组和干预组各60例。对照组实行常规护理，干预组在对照组基础上定期电话随访宣讲肝硬化失代偿期综合防治的自我管理指导。比较2组1年后停药率、再住院率、HBV DNA 阴转率、原发性肝癌发生率和病死率。计量资料的比较采用 t检验，计数资料的比较采用卡方检验或 Fisher 精确检验。结果干预组停药率和住院率分别为0和18．3％，对照组分别为8．3％和35.0％，2组比较差异有统计学意义（P 值均＜0．05）。干预组 HBV DNA 阴转率、原发性肝癌发生率和病死率分别为90.0％、3.3％、5．3％，对照组分别为88．3％、5％、6．7％，2组比较差异无统计学意义（P 值均＞0．05）。结论加强失代偿期乙型肝炎肝硬化恩替卡韦抗病毒治疗患者的自我管理，并对其经常性的健康宣教可以增加患者的依从性，有利于康复。
目的：探討加彊自我管理對乙型肝炎肝硬化失代償期患者恩替卡韋抗病毒治療的依從性及療效的影響。方法選取2010年1月-2012年1月在福建醫科大學附屬泉州市第一醫院住院使用恩替卡韋抗病毒治療的乙型肝炎肝硬化失代償期患者120例，隨機分為對照組和榦預組各60例。對照組實行常規護理，榦預組在對照組基礎上定期電話隨訪宣講肝硬化失代償期綜閤防治的自我管理指導。比較2組1年後停藥率、再住院率、HBV DNA 陰轉率、原髮性肝癌髮生率和病死率。計量資料的比較採用 t檢驗，計數資料的比較採用卡方檢驗或 Fisher 精確檢驗。結果榦預組停藥率和住院率分彆為0和18．3％，對照組分彆為8．3％和35.0％，2組比較差異有統計學意義（P 值均＜0．05）。榦預組 HBV DNA 陰轉率、原髮性肝癌髮生率和病死率分彆為90.0％、3.3％、5．3％，對照組分彆為88．3％、5％、6．7％，2組比較差異無統計學意義（P 值均＞0．05）。結論加彊失代償期乙型肝炎肝硬化恩替卡韋抗病毒治療患者的自我管理，併對其經常性的健康宣教可以增加患者的依從性，有利于康複。
목적：탐토가강자아관리대을형간염간경화실대상기환자은체잡위항병독치료적의종성급료효적영향。방법선취2010년1월-2012년1월재복건의과대학부속천주시제일의원주원사용은체잡위항병독치료적을형간염간경화실대상기환자120례，수궤분위대조조화간예조각60례。대조조실행상규호리，간예조재대조조기출상정기전화수방선강간경화실대상기종합방치적자아관리지도。비교2조1년후정약솔、재주원솔、HBV DNA 음전솔、원발성간암발생솔화병사솔。계량자료적비교채용 t검험，계수자료적비교채용잡방검험혹 Fisher 정학검험。결과간예조정약솔화주원솔분별위0화18．3％，대조조분별위8．3％화35.0％，2조비교차이유통계학의의（P 치균＜0．05）。간예조 HBV DNA 음전솔、원발성간암발생솔화병사솔분별위90.0％、3.3％、5．3％，대조조분별위88．3％、5％、6．7％，2조비교차이무통계학의의（P 치균＞0．05）。결론가강실대상기을형간염간경화은체잡위항병독치료환자적자아관리，병대기경상성적건강선교가이증가환자적의종성，유리우강복。
Objective To investigate the effect of strengthening self -management on the treatment compliance and outcome in hepatitis B patients with decompensated cirrhosis treated with entecavir.Methods A total of 120 hepatitis B patients with decompensated cirrhosis, who received antiviral therapy with entecavir in our hospital from January 2010 to January 2012,were randomly divided into control group (n=60)and intervention group (n =60).Both groups received routine nursing care;in addition,regular telephone follow -up was performed for the intervention group to provide guidance for the self -management during the comprehensive prevention and treatment of decompensated cirrhosis.The two groups were compared in terms of withdrawal rate,rehospitalization rate,hepatitis B virus (HBV)DNA negative conver-sion rate,incidence of primary liver cancer,and mortality one year later.Continuous data were analyzed by t test,and categorical data by chi -square test or Fisher′s exact test.Results The withdrawal rate and rehospitalization rate in the intervention group were 0 and 18.3%, respectively,versus 8.3% and 35% in the control group (P <0.05 for both).The HBV DNA negative conversion rate,incidence of prima-ry liver cancer,and mortality in the intervention group were 90%,3.3%,and 5.3%,versus 88.3%,5%,and 6.7% in the control group (P >0.05 for all).Conclusion Strengthening self -management,as well as regular health education,can improve treatment compliance and promote recovery in hepatitis B patients with decompensated cirrhosis treated with entecavir.
