CAJ | 학술논문

目的：探讨轻度认知障碍（MCI）患者脑脊液中β-淀粉样蛋白42（Aβ42）与磷酸化Tau蛋白（P-tau）水平变化及其意义。方法：采用ELISA法检测25例MCI患者和14例认知功能正常者脑脊液标本中Aβ42和P-tau水平，并对MCI患者脑脊液中P-tau和MMSE评分进行相关统计学分析。结果：MCI组脑脊液中Aβ42水平低于对照组，P-tau水平高于对照组，差异有统计学意义（P＜0．05）。简单相关分析及校正受教育程度后的偏相关分析显示MCI组脑脊液中P-tau水平与MMSE评分呈负相关（P＜0．05）。结论：脑脊液中Aβ42和P-tau水平可能为MCI诊断提供依据。 MCI患者中脑脊液P-tau水平可能与认知障碍的严重程度有关。
목적：탐토경도인지장애（MCI）환자뇌척액중β-정분양단백42（Aβ42）여린산화Tau단백（P-tau）수평변화급기의의。방법：채용ELISA법검측25례MCI환자화14례인지공능정상자뇌척액표본중Aβ42화P-tau수평，병대MCI환자뇌척액중P-tau화MMSE평분진행상관통계학분석。결과：MCI조뇌척액중Aβ42수평저우대조조，P-tau수평고우대조조，차이유통계학의의（P＜0．05）。간단상관분석급교정수교육정도후적편상관분석현시MCI조뇌척액중P-tau수평여MMSE평분정부상관（P＜0．05）。결론：뇌척액중Aβ42화P-tau수평가능위MCI진단제공의거。 MCI환자중뇌척액P-tau수평가능여인지장애적엄중정도유관。
Objective To investigate Aβ42 and P-tau levels in cerebrospinal fluid (CSF) of patients with mild cognitive impairment (MCI). Methods CSF of 25 cases of MCI and 14 cases of cognitively normal (CN) were investigated. The CSF levels of Aβ42 and P-tau were detected by ELISA method. Correlation analysis was used to analyze the correlation between P-tau level and MMSE score in MCI. Results The CSF level of Aβ 42 was higher and P-tau was lower in MCI than CN group(P<0.05). P-tau level in MCI was also negatively correlated with MMSE score (P<0.05). Conclusion Aβ42 and P-tau levels in CSF may be valuable biological markers in the diagnosis of MCI. P-tau level in CSF of MCI may be related to the severity of cognitive impairment.