CAJ | 학술논문

目的：观察三尖瓣关闭不全（TR）致右心重构比格犬模型的病理生理学变化。方法：将6只比格犬随机分为TR组和假手术组，每组3只。 TR组采用心脏不停跳直视下剪除三尖瓣前、后瓣叶，造成极重度TR。运用超声心动图分别于术前和术后3、6、12个月进行检查，18个月后处死，Masson染色检查心肌纤维化程度。结果：手术成功率100％，存活率100％。 TR组体重逐渐增加，超声心动图提示右房、右室增大，右心功能减退，病理检查发现TR组心肌纤维化、肝损害及大量腹水，提示发生右心重构和右心衰竭。假手术组手术前后未见差异。结论：TR组右心功能逐渐减退，并且心肌纤维化明显，是导致右心重构的病理基础之一。
목적：관찰삼첨판관폐불전（TR）치우심중구비격견모형적병리생이학변화。방법：장6지비격견수궤분위TR조화가수술조，매조3지。 TR조채용심장불정도직시하전제삼첨판전、후판협，조성겁중도TR。운용초성심동도분별우술전화술후3、6、12개월진행검사，18개월후처사，Masson염색검사심기섬유화정도。결과：수술성공솔100％，존활솔100％。 TR조체중축점증가，초성심동도제시우방、우실증대，우심공능감퇴，병리검사발현TR조심기섬유화、간손해급대량복수，제시발생우심중구화우심쇠갈。가수술조수술전후미견차이。결론：TR조우심공능축점감퇴，병차심기섬유화명현，시도치우심중구적병리기출지일。
Objective To observe the pathophysiological change of right heart remodeling model of beagle dogs caused by tricuspid regurgitation. Methods Six beagle dogs were separated to TR group and sham operation group randomly and equally. The anterior and posterior leaflets of tricuspid valve of beagle dogs from TR group were cut off under direct vision on the beating heart. The echocardiography data were measured pre-operation and post-operation 3, 6, 12 months respectively and autopsy results were acquired after the sacrifice of two animals who had been raised for 18 months. Results The operation was successful and survival 100%. The weight of TR group increased, and the echocardiography showed right atrium and ventricle enlargement and right heart dysfunction. The autopsy of TR group found myocardial fibrosis , liver cirrhosis and ascites. All of the results indicated the occurrence of right heart remodeling and right heart failure. There is no significant difference in sham operation group before or after operation. Conclusion The myocardial fibrosis is one of the pathological basis of right heart remodeling.