CAJ | 학술논문

目的：探讨冠心病患者血清胱抑素 C（Cys C）水平与冠状动脉病变严重程度的相关性。方法选择2013年1月至2014年1月重庆市第五人民医院心内科收治的80例冠心病患者为冠心病组，依据冠状动脉病变范围分为单支病变亚组（A 组）31例、双支病变亚组（B 组）25例和多支病变亚组（C 组）24例。同时选取32例冠状动脉正常患者为对照组。对患者的体质量指数（BMI）、血清 Cys C 、血清总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、空腹血糖（FPG）、肌酐（Cr）等指标进行检测并比较。结果冠心病组与对照组患者 BMI 、TC 、TG 、HDL-C 、FPG 、Cr 水平对比，差异无统计学意义（P ＞0．05）；血清 Cys C 及 MM P-9对比，差异有统计学意义（P＜0．05）。对冠心病组各亚组间进行分析，B 、C 组在血清 Cys C 及 MMP-9方面与 A 组比较，差异有统计学意义（P＜0．05）；C 组血清 Cys C 及 MMP-9与 B 组相比，差异有统计学意义（P＜0．05）。相关性分析发现，血清 Cys C与 BMI 、TG 、MMP-9和冠状动脉病变支数具有负相关性（r ＝-0．448、-0．397、-0．476、-0．527，P＜0．05），血清Cys C 与 HDL-C 具有正相关性（r＝0．283，P＜0．05）。结论 Cys C 水平与患者发生动脉粥样硬化紧密相关，可通过检测 Cys C 对冠心病进行筛查及病变严重程度评估。
목적：탐토관심병환자혈청광억소 C（Cys C）수평여관상동맥병변엄중정도적상관성。방법선택2013년1월지2014년1월중경시제오인민의원심내과수치적80례관심병환자위관심병조，의거관상동맥병변범위분위단지병변아조（A 조）31례、쌍지병변아조（B 조）25례화다지병변아조（C 조）24례。동시선취32례관상동맥정상환자위대조조。대환자적체질량지수（BMI）、혈청 Cys C 、혈청총담고순（TC）、삼선감유（TG）、고밀도지단백담고순（HDL-C）、공복혈당（FPG）、기항（Cr）등지표진행검측병비교。결과관심병조여대조조환자 BMI 、TC 、TG 、HDL-C 、FPG 、Cr 수평대비，차이무통계학의의（P ＞0．05）；혈청 Cys C 급 MM P-9대비，차이유통계학의의（P＜0．05）。대관심병조각아조간진행분석，B 、C 조재혈청 Cys C 급 MMP-9방면여 A 조비교，차이유통계학의의（P＜0．05）；C 조혈청 Cys C 급 MMP-9여 B 조상비，차이유통계학의의（P＜0．05）。상관성분석발현，혈청 Cys C여 BMI 、TG 、MMP-9화관상동맥병변지수구유부상관성（r ＝-0．448、-0．397、-0．476、-0．527，P＜0．05），혈청Cys C 여 HDL-C 구유정상관성（r＝0．283，P＜0．05）。결론 Cys C 수평여환자발생동맥죽양경화긴밀상관，가통과검측 Cys C 대관심병진행사사급병변엄중정도평고。
Objective To investigate the relationship between serum cystatin C (Cys C)level and the severity of coronary artery disease(CHD) .Methods A total of 80 patients with CHD were chosen into CHD group from depart-ment of cardiology of the Fifth People′s Hospital of Chongqing ,and divided into group A(31 patients with single-ves-sel disease) ,B group(25 patients with double-vessel disease)and group C(24 patients with more than two vessel dis-ease)according to the area of coronary artery stenosis .Other 32 cases without CHD were selected into the control group .The body mass index(BMI) ,serum Cys C ,total cholesterol(TC) ,triglycerides(TG) ,high density lipoprotein cholesterol(HDL-C) ,fasting plasma glucose(FPG) ,creatinine(Cr)and other indicators were detected .Results There were no significant differences on the level of BMI 、TC 、TG 、HDL-C 、FPG 、Cr between the CHD group and the control group(P> 0 .05 ) ,but significant differences were found on Cys C and matrix metalloproteinase 9 (MMP-9)( P <0 .05) .Compared with group A ,group B and group C had significant differences on serum Cys C and MMP-9(P >0 .05) ,and there was a significant difference on the Cys C and MMP-9 between group C and group B(P< 0 .05) .Cor-relation analysis shown that there were significant negative correlation between serum Cys C and BMI ,TG ,MMP-9 and coronary artery lesions(r= - 0 .448 ,- 0 .397 ,- 0 .476 ,- 0 .527 ,P< 0 .05) ,and serum Cys C and HDL-C had a significant positive correlation(r= 0 .283 ,P < 0 .05) .Conclusion Level of Cys C in patients with atherosclerosis is closely related to the occurrence and development of carotid atherosclerosis .