CAJ | 학술논문

目的：了解广西南宁地区异常血红蛋白 Hb Q-Thailand 分子特征。方法回顾性分析2013年1月至2014年1月来广西壮族自治区妇幼保健院?儿童医院做地贫筛查的23026例患者资料，通过毛细管电泳方法，确定可疑 Hb Q-Thailand 患者，运用扩增不应突变系统对可疑阳性患者进行确诊。结果在23026例中共确诊Hb Q-Thailand 阳性患者29例，占筛查人数的0．13％。且有1例是我国首次发现的 Hb Q-Thailand 不与4．2左侧缺失型α-地贫连锁的患者。结论 Hb Q-Thailand 作为异常血红蛋白的一种，有其独特的分子特征，在日常工作中应引起足够的重视。
목적：료해엄서남저지구이상혈홍단백 Hb Q-Thailand 분자특정。방법회고성분석2013년1월지2014년1월래엄서장족자치구부유보건원?인동의원주지빈사사적23026례환자자료，통과모세관전영방법，학정가의 Hb Q-Thailand 환자，운용확증불응돌변계통대가의양성환자진행학진。결과재23026례중공학진Hb Q-Thailand 양성환자29례，점사사인수적0．13％。차유1례시아국수차발현적 Hb Q-Thailand 불여4．2좌측결실형α-지빈련쇄적환자。결론 Hb Q-Thailand 작위이상혈홍단백적일충，유기독특적분자특정，재일상공작중응인기족구적중시。
Objective To understand the molecular features of abnormal hemoglobin Hb Q-Thailand in Nan-ning city of Guangxi Zhuang autonomous region .Methods Data of 23 026 patients screened thalassemia were ana-lyzed retrospectively .Capillary electrophoresis were used to determine the suspicious patients with HB Q-Thailand , and ARMS-PCR method was applied to make a definite diagnosis among suspected positive patients .Results A total of 29 patients in 23 026 suspicious patients were confirmed as HB Q-Thailand positive 29 cases ,accounted for 0 .13% of the number of screening .Conclusion HB Q-Thailand as a kind of abnormal hemoglobin ,has unique molec-ular characteristics and a certain occurrence rate in Nanning ,should be causes enough attention in daily work .