CAJ | 학술논문

目的：评估全自动毛细管血红蛋白（Hb）电泳技术在深圳地区妊娠妇女产前珠蛋白生成障碍性贫血（地贫）筛查及异常 Hb 检查的临床应用价值。方法采用 Sebia capillary2flex 型全自动毛细管电泳仪对深圳市龙岗区妇幼保健院产前门诊孕妇进行 Hb 电泳检测，分析 HbA2水平及异常 Hb 电泳条带及水平。结果检出951例异常 Hb 电泳结果（异常率9．9％）包括 HbA2＞3．5％；HbA2＜2．5％；HbF ＞10％及其他异常 Hb（包括 HbCS 、HbE 、HbD 、Hb NewYork 和 Hb Q-Tailand 等）。结论全自动毛细管 Hb 电泳在地贫产前筛查及异常 Hb 检测中具有重要意义，可为进一步分子确诊及产前诊断提供指导。
목적：평고전자동모세관혈홍단백（Hb）전영기술재심수지구임신부녀산전주단백생성장애성빈혈（지빈）사사급이상 Hb 검사적림상응용개치。방법채용 Sebia capillary2flex 형전자동모세관전영의대심수시룡강구부유보건원산전문진잉부진행 Hb 전영검측，분석 HbA2수평급이상 Hb 전영조대급수평。결과검출951례이상 Hb 전영결과（이상솔9．9％）포괄 HbA2＞3．5％；HbA2＜2．5％；HbF ＞10％급기타이상 Hb（포괄 HbCS 、HbE 、HbD 、Hb NewYork 화 Hb Q-Tailand 등）。결론전자동모세관 Hb 전영재지빈산전사사급이상 Hb 검측중구유중요의의，가위진일보분자학진급산전진단제공지도。
Objective To evaluate the clinical value of the automatic capillary hemoglobin electrophoresis tech -nology in both the screening of prenatal thalassaemia and the detection of abnormal hemoglobin in pregnant women in Shenzhen .Methods The Sebia capillary 2-type automatic capillary electrophoresis apparatus was employed to detect the hemoglobin electrophoresis spectrum of the 9 569 prenatal outpatients .The content of hemoglobin A2 ,the bands and contents of other abnormal hemoglobins were analyzed .Results Abnormal hemoglobin electrophoresis spectrum was detected in 951 prenatal outpatients (with an abnormal detection rate of 9 .9% ) ,including hemoglobin A2 >3 .5% ,hemoglobin A2 < 2 .5% ,hemoglobin F > 10% and other abnormal hemoglobins(including hemoglobin CS ,he-moglobin D ,hemoglobin E ,hemoglobin NewYork and hemoglobin Q-Tailand ,etc) .Conclusion Automatic capillary hemoglobin electrophoresis is of great significance in the screening of prenatal thalassaemia and the detection of ab -normal hemoglobin in pregnant women ,which could provide guidance for further definite molecular diagnosis and pre-natal diagnosis .