中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2014年
5期
420-422
,共3页
任婧%陈新贵%韩永升%马慧娟%汪凯
任婧%陳新貴%韓永升%馬慧娟%汪凱
임청%진신귀%한영승%마혜연%왕개
肝豆状核变性病%记忆监测%知道感
肝豆狀覈變性病%記憶鑑測%知道感
간두상핵변성병%기억감측%지도감
Wilson's disease%Memory monitoring%Feeling-of-knowing
目的 研究肝豆状核变性病(H LD)患者记忆监测的情况,同时探讨HLD患者记忆障碍的可能机制.方法 建立情景记忆(EM)及语义记忆(SM)的知道感(FOK)实验范式,对30例HLD患者及30例年龄及教育程度相匹配的健康对照者(HC)进行研究.结果 与HC组的FOK-EM的线索回忆率[(64.17±29.21)％]以及FOK-SM的线索回忆率[(84.72±11.44)％]比较,HLD患者组FOK-EM的线索回忆率[(26.55±20.92)％]、FOK-SM的线索回忆率[(53.93±28.42)％]显著降低,差异有统计学意义(t=-5.140,P＜0.01;t=-5.123,P＜0.01);FOK-EM的肯定判断/正确再认成绩[(50.64±29.43)％]、否定判断/正确再认成绩[(12.80±18.32)％]与HC组的肯定判断/正确再认成绩[(75.15±31.73)％]、否定判断/正确再认成绩[(1.81±5.41)％]之间差异有统计学意义(t=-2.693,P＜0.05;t=3.026,P＜0.01);且stroop效应与FOK-EM的否定判断/正确再认成绩呈正相关(r=0.601,P＜0.01).结论 HLD患者在情景记忆FOK中表现为对自身再认能力的低估,低估程度与执行功能的损害相关,提示前额叶功能损伤可能是导致HLD患者情景记忆障碍的重要因素,同时相对保留的语义记忆FOK提示二者可能依赖不同的神经机制.
目的 研究肝豆狀覈變性病(H LD)患者記憶鑑測的情況,同時探討HLD患者記憶障礙的可能機製.方法 建立情景記憶(EM)及語義記憶(SM)的知道感(FOK)實驗範式,對30例HLD患者及30例年齡及教育程度相匹配的健康對照者(HC)進行研究.結果 與HC組的FOK-EM的線索迴憶率[(64.17±29.21)％]以及FOK-SM的線索迴憶率[(84.72±11.44)％]比較,HLD患者組FOK-EM的線索迴憶率[(26.55±20.92)％]、FOK-SM的線索迴憶率[(53.93±28.42)％]顯著降低,差異有統計學意義(t=-5.140,P＜0.01;t=-5.123,P＜0.01);FOK-EM的肯定判斷/正確再認成績[(50.64±29.43)％]、否定判斷/正確再認成績[(12.80±18.32)％]與HC組的肯定判斷/正確再認成績[(75.15±31.73)％]、否定判斷/正確再認成績[(1.81±5.41)％]之間差異有統計學意義(t=-2.693,P＜0.05;t=3.026,P＜0.01);且stroop效應與FOK-EM的否定判斷/正確再認成績呈正相關(r=0.601,P＜0.01).結論 HLD患者在情景記憶FOK中錶現為對自身再認能力的低估,低估程度與執行功能的損害相關,提示前額葉功能損傷可能是導緻HLD患者情景記憶障礙的重要因素,同時相對保留的語義記憶FOK提示二者可能依賴不同的神經機製.
목적 연구간두상핵변성병(H LD)환자기억감측적정황,동시탐토HLD환자기억장애적가능궤제.방법 건립정경기억(EM)급어의기억(SM)적지도감(FOK)실험범식,대30례HLD환자급30례년령급교육정도상필배적건강대조자(HC)진행연구.결과 여HC조적FOK-EM적선색회억솔[(64.17±29.21)％]이급FOK-SM적선색회억솔[(84.72±11.44)％]비교,HLD환자조FOK-EM적선색회억솔[(26.55±20.92)％]、FOK-SM적선색회억솔[(53.93±28.42)％]현저강저,차이유통계학의의(t=-5.140,P＜0.01;t=-5.123,P＜0.01);FOK-EM적긍정판단/정학재인성적[(50.64±29.43)％]、부정판단/정학재인성적[(12.80±18.32)％]여HC조적긍정판단/정학재인성적[(75.15±31.73)％]、부정판단/정학재인성적[(1.81±5.41)％]지간차이유통계학의의(t=-2.693,P＜0.05;t=3.026,P＜0.01);차stroop효응여FOK-EM적부정판단/정학재인성적정정상관(r=0.601,P＜0.01).결론 HLD환자재정경기억FOK중표현위대자신재인능력적저고,저고정도여집행공능적손해상관,제시전액협공능손상가능시도치HLD환자정경기억장애적중요인소,동시상대보류적어의기억FOK제시이자가능의뢰불동적신경궤제.
Objective To investigate the memory monitoring ability in patients with hepatolenticular degeneration(HLD) and explore the mechanism of their memory impairment.Methods The feeling-of-knowing (FOK) paradigm of episodic memory(EM) and semantic memory(SM)were established and subsequently applied to 30 HLD patients and 30 healthy control(HC) participants who were matched in age and educational level.Results Compared with healthy control group (FOK-EM recall (64.17 ± 29.21) ％ ; FOK-SM recall (84.72 ± 11.44)％),the FOK-EM recall((26.55±20.92)％) and FOK-SM recall((53.93±28.42)％) in HLD patients were significantly lower(t=-5.140,P＜0.01 ; t=-5.123,P＜0.01).The positive judgment and correct recognition of FOK-EM ((50.64±29.43) ％) and the negative judgment and correct recognition of FOK-EM((12.80± 18.32) ％) in the HLD group were significantly different from the HC group (the positive judgment and correct recognition of FOK-EM:(75.15±31.73)％ and the false judgment and correct recognition of FOK-EM:(1.81±5.41)％; t=-2.693,P＜0.05 ; t=3.026,P＜0.01).Most importantly,the stroop effect was positively correlated with the negative judgment and correct recognition of FOK-EM in HLD group(r=0.601,P＜0.01).Conclusion The results show that the HLD group underestimate their memory performance on episodic FOK,and the impairment of memory monitoring is positively correlated with the deficit of executive function,indicating that the prefrontal impairment can be an influential factor of memory disorder in HLD,whereas the unimpaired semantic metamemory FOK indicates the episodic and semantic metamemory monitoring may depend on different neural network.
