中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2014年
5期
405-407
,共3页
韩易%傅先明%钱若兵%林彬%袁季%魏祥品%牛朝诗%汪业汉
韓易%傅先明%錢若兵%林彬%袁季%魏祥品%牛朝詩%汪業漢
한역%부선명%전약병%림빈%원계%위상품%우조시%왕업한
阿片类药物依赖%伏隔核%线索诱导%功能磁共振%功能连接
阿片類藥物依賴%伏隔覈%線索誘導%功能磁共振%功能連接
아편류약물의뢰%복격핵%선색유도%공능자공진%공능련접
Opiate drag addiction%Nucleus accumbens%Cue-elicited%Functional magnetic resonance imaging%Functional connectivity
目的 探讨生理脱毒期阿片类药物依赖者线索诱发作业下与伏隔核存在异常功能连接的脑区及其在戒断复吸中的作用.方法 生理脱毒期阿片类药物依赖组和健康对照组各18例,在观看与阿片类药物依赖线索相关视频时进行功能磁共振成像扫描,分别选取左、右侧伏隔核为感兴趣区进行功能连接分析,确定与双侧伏隔核存在功能连接的脑区.结果 与健康对照组相比,生理脱毒期阿片类药物依赖组的伏隔核与前额叶(46,29,-9)、岛叶(31,25,-7)、后扣带回(4,-59,19)、楔前叶(4,-63,22)、枕叶(6,71,16)、舌回(11,-37,-8)和距状回(3,-45,7)的功能连接明显高于健康对照组,而与丘脑(-8,-13,2)、前扣带回(-2,44,20)功能连接明显低于健康对照组(P＜0.05).结论 生理脱毒期阿片类药物依赖者线索诱导下的伏隔核存在功能异常,这可能是其容易复吸的重要原因之一.
目的 探討生理脫毒期阿片類藥物依賴者線索誘髮作業下與伏隔覈存在異常功能連接的腦區及其在戒斷複吸中的作用.方法 生理脫毒期阿片類藥物依賴組和健康對照組各18例,在觀看與阿片類藥物依賴線索相關視頻時進行功能磁共振成像掃描,分彆選取左、右側伏隔覈為感興趣區進行功能連接分析,確定與雙側伏隔覈存在功能連接的腦區.結果 與健康對照組相比,生理脫毒期阿片類藥物依賴組的伏隔覈與前額葉(46,29,-9)、島葉(31,25,-7)、後釦帶迴(4,-59,19)、楔前葉(4,-63,22)、枕葉(6,71,16)、舌迴(11,-37,-8)和距狀迴(3,-45,7)的功能連接明顯高于健康對照組,而與丘腦(-8,-13,2)、前釦帶迴(-2,44,20)功能連接明顯低于健康對照組(P＜0.05).結論 生理脫毒期阿片類藥物依賴者線索誘導下的伏隔覈存在功能異常,這可能是其容易複吸的重要原因之一.
목적 탐토생리탈독기아편류약물의뢰자선색유발작업하여복격핵존재이상공능련접적뇌구급기재계단복흡중적작용.방법 생리탈독기아편류약물의뢰조화건강대조조각18례,재관간여아편류약물의뢰선색상관시빈시진행공능자공진성상소묘,분별선취좌、우측복격핵위감흥취구진행공능련접분석,학정여쌍측복격핵존재공능련접적뇌구.결과 여건강대조조상비,생리탈독기아편류약물의뢰조적복격핵여전액협(46,29,-9)、도협(31,25,-7)、후구대회(4,-59,19)、설전협(4,-63,22)、침협(6,71,16)、설회(11,-37,-8)화거상회(3,-45,7)적공능련접명현고우건강대조조,이여구뇌(-8,-13,2)、전구대회(-2,44,20)공능련접명현저우건강대조조(P＜0.05).결론 생리탈독기아편류약물의뢰자선색유도하적복격핵존재공능이상,저가능시기용역복흡적중요원인지일.
Objective To explore the brain areas which have abnormal functional connectivity with nucleus accumbens in opiate drug addicts during physical detoxification nsing a cue-elicited task-related functional magnetic resonance imaging (fMRI),and to find out the role of nucleus accumbens dysfunction in the relapse of opiate drug dependence during physical detoxification.Methods Eighteen participants of opiate drug addicts during physical detoxification,and eighteen healthy controls performed a cue-elicited craving task in a MRI scanner while signal data were collected.The left and right nucleus accumbens were selected as regions of interest (ROIs) respectively,and calculated the linear correlation between the nucleus accumbens and the entire brain to find out the functional connectivity of the nucleus accumbens.Results Compared with the controls,the functional connectivity between the nucleus accumbens and the prefrontal cortex (46,29,-9),insula(3 1,25,-7),posterior cingutate (4,-59,19),precuneus(4,-63,22),occipital lobe(6,71,16),lingual gyrus(11,-37,-8),calcarine (3,-45,7) in the opiate drug addicts during physical detoxification group were increased(P＜0.05),and the functional connectivity between the nucleus accumbens and thalamus(-8,-13,2),anterior cingutate(-2,44,20) were decreased(P＜0.05).Conclusion The nucleus accumbens dysfunction of functional connectivity in a cue-elicited craving task may play a important role in the relapse of opiate drug dependence during physical detoxification.
