CAJ | 학술논문

本研究旨在探讨不同剂量、粒径的毛木耳细粉对SD大鼠高脂性饮食诱发肥胖的减肥降脂功效。利用高脂饲料诱发 SD 大鼠肥胖模型2周后，给予不同粒径（300～400目和＞400目）、剂量（1250、1000和750 mg/kg）的毛木耳细粉42 d，干预期间检测动物体重、摄食量，干预结束时检测动物血脂、体脂、体重。结果表明：肥胖模型建立成功，各组大鼠摄食总量、摄入总热量及食物利用率无显著差异（ P＞0．05），1250和1000 mg/kg的300～400目和＞400目的毛木耳细粉均可显著降低肥胖模型大鼠的体重和体增重（ P＜0．05）。1250 mg/kg的300～400目和＞400目毛木耳细粉可降低肥胖模型大鼠的脂重、脂/体比及血清总胆固醇、低密度脂蛋白胆固醇含量（ P＜0．05或P＜0．01）。由此可见，300～400目和＞400目毛木耳细粉的动物减肥降脂功能试验结果阳性。
본연구지재탐토불동제량、립경적모목이세분대SD대서고지성음식유발비반적감비강지공효。이용고지사료유발 SD 대서비반모형2주후，급여불동립경（300～400목화＞400목）、제량（1250、1000화750 mg/kg）적모목이세분42 d，간예기간검측동물체중、섭식량，간예결속시검측동물혈지、체지、체중。결과표명：비반모형건립성공，각조대서섭식총량、섭입총열량급식물이용솔무현저차이（ P＞0．05），1250화1000 mg/kg적300～400목화＞400목적모목이세분균가현저강저비반모형대서적체중화체증중（ P＜0．05）。1250 mg/kg적300～400목화＞400목모목이세분가강저비반모형대서적지중、지/체비급혈청총담고순、저밀도지단백담고순함량（ P＜0．05혹P＜0．01）。유차가견，300～400목화＞400목모목이세분적동물감비강지공능시험결과양성。
In order to study the effects of Auricularia polytricha powder with different doses on weight loss and lowering blood lipid of high-fat nutritional diet-induced obesity SD rats. SD rats were used as obesity models by feeding them with high fat nutrition for 2 weeks, followed by administrating with different partical size ( 300 to 400 mesh and more than 400 mesh) or dose (1 250, 1 000 and 750 mg/kg) of Auricularia polytricha powder for 42 days. Body weight and food intake of rats were recorded. Meanwhile, the lipid levels in blood and body also were calculated after intervention. The results showed that animal model was made successfully, and there was no significant difference in total food and calorie intake and food utilization rate of rats among all groups ( P>0.05) . However, 300 to 400 mesh and more than 400 mesh of Auricularia polytricha powder with high dose ( 1 250 g/kg ) and medium dose ( 1 000 g/kg ) could significantly reduce the body weight and body weight gain of obesity rats than those in the model control group ( P<0.05) . Fat weight, fat body ratio, serum total cholesterol and low density lipoprotein cholesterol ( LDL-C) contents of rats fed with 300 to 400 mesh high dose or more than 400 mesh high dose were significantly lower than those of the model control group. It can be concluded that 300 to 400 mesh and more than 400 mesh of Auricularia polytricha powder possesses certain effects both on weight loss and lipid-lowering.