CAJ | 학술논문

多胺具有调控细胞增殖、分化和凋亡的功能，可参与动物繁殖、胚胎发育以及癌症发生发展等多种生物学过程。在动物机体中，多胺稳态是通过多胺跨膜物质转运和多胺代谢途径共同维持的。溶质转运蛋白（ SLC ）基因家族中的 SLC3A2、SLC7A1、SLC12A8、SLC22A16、SLC22A1、SLC22A2、SLC22A3基因及其编码的蛋白质可参与多胺的跨膜物质转运；多胺代谢关键调控基因鸟氨酸脱羧酶（ ODC ）、鸟氨酸脱羧酶抗酶（ OAZ ）和鸟氨酸脱羧酶抗酶抑制剂（ AZIN）对多胺跨膜物质转运也具有重要的调控功能；此外，金属阳离子、细胞膜跨膜电位和pH等内环境因素也可参与多胺转运的调节。因此，本文就多胺转运蛋白、多胺代谢相关基因和蛋白质以及内环境因素调控多胺跨膜物质转运的分子调控机制作一综述，以期为阐明多胺转运调控机制的研究奠定理论基础。
다알구유조공세포증식、분화화조망적공능，가삼여동물번식、배태발육이급암증발생발전등다충생물학과정。재동물궤체중，다알은태시통과다알과막물질전운화다알대사도경공동유지적。용질전운단백（ SLC ）기인가족중적 SLC3A2、SLC7A1、SLC12A8、SLC22A16、SLC22A1、SLC22A2、SLC22A3기인급기편마적단백질가삼여다알적과막물질전운；다알대사관건조공기인조안산탈최매（ ODC ）、조안산탈최매항매（ OAZ ）화조안산탈최매항매억제제（ AZIN）대다알과막물질전운야구유중요적조공공능；차외，금속양리자、세포막과막전위화pH등내배경인소야가삼여다알전운적조절。인차，본문취다알전운단백、다알대사상관기인화단백질이급내배경인소조공다알과막물질전운적분자조공궤제작일종술，이기위천명다알전운조공궤제적연구전정이론기출。
Polyamines are involved in several biological processes including reproduction, embryo development and cancer development, as well as play important roles in cell proliferation, differentiation and apoptosis. The homeostasis of polyamines is regulated strictly by transmembrane transporter and polyamine metabolically path-ways. Solute carrier ( SLC ) gene family including SLC3A2, SLC7A1, SLC12A8, SLC22A16, SLC22A1, SLC22A2 and SLC22A3 genes and their protein could involve in the process of polyamine transmembrane trans-port; furthermore, the key regulatory genes of polyamine metabolism including ornithine decarboxylase ( ODC ) , ornithine decarboxylase antizyme ( OAZ ) and ornithine decarboxylase antizyme inhibitorgenes ( AZIN) genes could also regulate transmembrane transport of polyamines;moreover, the internal environmen-tal factors including metal cation, transmembrane potential and pH also involved in the process of polyamine transport. Therefore, in this paper, the roles of the polyamine transporters, the key regulatory genes of poly-amine metabolism and their proteins, and internal environmental factors mediating polyamine transport were re-viewed.