CAJ | 학술논문

自脂肪量和肥胖相关（ FTO）基因发现以来，其生物学功能研究已取得不少进展。 FTO基因广泛地分布于生物界，并在动物多种组织中表达，其中在下丘脑中表达量最高。 FTO基因在下丘脑中的作用主要是调节食欲和能量代谢，而在其他组织中的作用还有待深入研究。 FTO蛋白如何发挥其作为核酸修饰酶的功能目前仍不清楚。有大量数据表明，FTO基因多态性不仅与肥胖和肥胖相关性状（如身体质量指数、腰围、腰臀比例、上臂宽和上臂围）存在强相关，而且也与肥胖诱发的许多疾病，如心脏病、2型糖尿病和癌症等有关。此外，FTO基因在动物生长发育、能量代谢平衡、脂肪代谢、炎症反应和癌细胞增殖等方面起重要作用。本文对FTO基因的生物学功能及其与动物生产的关系进行综述。
자지방량화비반상관（ FTO）기인발현이래，기생물학공능연구이취득불소진전。 FTO기인엄범지분포우생물계，병재동물다충조직중표체，기중재하구뇌중표체량최고。 FTO기인재하구뇌중적작용주요시조절식욕화능량대사，이재기타조직중적작용환유대심입연구。 FTO단백여하발휘기작위핵산수식매적공능목전잉불청초。유대량수거표명，FTO기인다태성불부여비반화비반상관성상（여신체질량지수、요위、요둔비례、상비관화상비위）존재강상관，이차야여비반유발적허다질병，여심장병、2형당뇨병화암증등유관。차외，FTO기인재동물생장발육、능량대사평형、지방대사、염증반응화암세포증식등방면기중요작용。본문대FTO기인적생물학공능급기여동물생산적관계진행종술。
Since fat mass and obesity-associated ( FTO) gene was discovered, rapid progress has been made in the studies of biological functions of FTO gene. FTO gene widely exists in the various animals, and is ex-pressed in different tissues of animals with the highest level of expression in the hypothalamus. The major role of FTO gene is to regulate appetite and energy metabolism in the hypothalamus, however, its role in other tis-sues remains unclear. Moreover, it is required to understand how FTO protein plays its biological functions as a nucleic acid modifying enzyme. Data indicated that the nucleotide polymorphism of FTO gene was not only strongly associated with obesity and obesity-related traits ( e. g. , body mass index, waist circumference, waist to hip ratio, upper arm width, and upper arm circumference) , but also associated with obesity-induced disea-ses including heart disease, type 2 diabetes, and cancer, etc. In addition, FTO gene has influences on animal growth and development, energy homeostasis, fat metabolism, inflammatory reaction, and cancer cell prolifer-ation, etc. This review summarized the biological functions of FTO gene and its relevance to animal produc-tion.