CAJ | 학술논문

目的：观察神经生长因子（NGF）对大鼠面神经挤压伤模型动作电位的影响，探讨其在面神经损伤修复过程中作用。方法：健康成年SD大白鼠35只，5只作为正常对照。其余30只分为A、B两组，均在双侧面神经下颊支作挤压伤模型。A组在损伤处的神经外膜下注入生理盐水，B组注入NGF。在1~5周内，每组每周各取3只动物作面神经电生理检查。结果：在面神经损伤后第1周，NGF组动作电位引出率高于生理盐水组。第2周之后，两组在动作电位引出率的差异无统计学意义。 A、B实验组在能引出动作电位的各时间段，与正常组比较，在面神经动作电位的传导速度、波幅、时程方面，组间差异无统计学意义。结论：NGF可以促进面神经挤压伤传导功能的早期恢复。
목적：관찰신경생장인자（NGF）대대서면신경제압상모형동작전위적영향，탐토기재면신경손상수복과정중작용。방법：건강성년SD대백서35지，5지작위정상대조。기여30지분위A、B량조，균재쌍측면신경하협지작제압상모형。A조재손상처적신경외막하주입생리염수，B조주입NGF。재1~5주내，매조매주각취3지동물작면신경전생리검사。결과：재면신경손상후제1주，NGF조동작전위인출솔고우생리염수조。제2주지후，량조재동작전위인출솔적차이무통계학의의。 A、B실험조재능인출동작전위적각시간단，여정상조비교，재면신경동작전위적전도속도、파폭、시정방면，조간차이무통계학의의。결론：NGF가이촉진면신경제압상전도공능적조기회복。
Objective: To investigate whether the NGF was related to the action potential of rat facial nerve following crush injuries. Methods:35 adult male SD rats were used in this study. 5 rats were normal controls. 30 rats were divided into group A and B. A crush injury was made at one branch of bilateral facial nerve. Group A: normal saline was injected into the injured site. Group B:NGF was injected into the injury site. Every 3 rats in each group were sacrificed for electro-physiological study at 1-, 2-, 3-, 4- and 5- weeks respectively. Results: In the first week after nerve injury, action poten-tials elicited rate of NGF group was higher than those in the saline group. No significant difference were found among groups on facial nerve conduction velocity, amplitude, and duration. Conclusion: NGF can promote the recovery of con-duction of facial nerve following crush injury.