CAJ | 학술논문

抗肿瘤靶向治疗是通过阻断癌细胞上与恶性程度（包括侵袭性、复发转移、生存率下降等）密切相关的特定分子靶点来抗癌的新技术。利用靶向药物减低肿瘤细胞增殖并提高放射敏感性,与放疗联合应用，有可能成为口腔颌面-头颈恶性肿瘤治疗新策略。目前已研制成功并开始在临床应用的分子靶向药物有表皮生长因子受体（epidermal growth factor receptor， EGFR）和血管内皮生长因子受体（vascular endothelial growth factor receptor，VFGFR）的抑制剂。利用分子诊断基因芯片检测肿瘤相关基因表达，可以制定出疗效更好的放疗联合个体化靶向治疗方案，来治疗口腔颌面-头颈恶性肿瘤。
항종류파향치료시통과조단암세포상여악성정도（포괄침습성、복발전이、생존솔하강등）밀절상관적특정분자파점래항암적신기술。이용파향약물감저종류세포증식병제고방사민감성,여방료연합응용，유가능성위구강합면-두경악성종류치료신책략。목전이연제성공병개시재림상응용적분자파향약물유표피생장인자수체（epidermal growth factor receptor， EGFR）화혈관내피생장인자수체（vascular endothelial growth factor receptor，VFGFR）적억제제。이용분자진단기인심편검측종류상관기인표체，가이제정출료효경호적방료연합개체화파향치료방안，래치료구강합면-두경악성종류。
Targeting cancer therapy is the new technique using molecular drugs selectively to block specific molecular target in tumor cells that related closely to malignant degree of tumor cell, including invasiveness, recurrence, metastasis and decreased survival rate, etc. Targeting therapy can potentially reduce tumor cell proliferation, progression, and increase radiosensitivity. Meanwhile, radiotherapy combined with targeting therapy should lead to new therapeutic strategies of oral and maxillofacial-head and neck carcinoma. Epidermal growth factor receptor (EGFR) inhibitors that specially anti EGFR overexpression and angiogenesis inhibitors that effects on vascular endothelial growth factor receptor (VFGFR) have been successfully developed and began their clinical application for oral and maxillofacial-head and neck carcinomas. The use of molecular diagnostic microarray for cancer related gene expression will be able to make a combining radiation and individualized targeting therapy to increase treatment effectiveness.