辽宁医学院学报
遼寧醫學院學報
료녕의학원학보
JOURNAL OF LIAONING MEDICAL UNIVERSITY
2014年
5期
20-24
,共5页
慢性肾脏疾病%肾小球滤过率%高尿酸血症
慢性腎髒疾病%腎小毬濾過率%高尿痠血癥
만성신장질병%신소구려과솔%고뇨산혈증
chronic kidney disease%glomerular filtration rate%hyperuricaemia
目的：探究慢性肾脏疾病(chronic kidney disease, CKD)与高尿酸血症(hyperuricemia)的关联性。方法选取弋矶山医院肾内科198例入院患者作为研究对象,开展横断面研究。进行肾小球滤过率(GFR)的测定(GFR<60 mL/min/1.73 m2定义为 CKD),并收集相关危险因素资料。选用多变量二分类 Logistic 回归分析来研究 UA 与 CKD 之间的相关性。结果多变量二分类 Logistic 回归分析显示,随着尿酸水平的升高, CKD 的患病风险呈上升趋势(趋势检验 P<0.05)。在调整了年龄,体重,体重指数(body mass index, BMI),血压、空腹血糖,总胆固醇(total cholesterol, TC),甘油三酯(triglyceride, TG)等影响因素后,与对照 UA 组相比,第2组患 CKD 的相对危险度( OR)为2.54(95% CI：1.51~4.83),第3组患 CKD 的 OR 值为4.65(95% CI：2.73~6.21),第4组患 CKD 的 OR 值为11.68(95% CI：6.41~15.92)。结论 CKD 与高尿酸血症之间存在相关性,随着 UA 水平的升高, CKD 的患病风险也逐渐升高。
目的：探究慢性腎髒疾病(chronic kidney disease, CKD)與高尿痠血癥(hyperuricemia)的關聯性。方法選取弋磯山醫院腎內科198例入院患者作為研究對象,開展橫斷麵研究。進行腎小毬濾過率(GFR)的測定(GFR<60 mL/min/1.73 m2定義為 CKD),併收集相關危險因素資料。選用多變量二分類 Logistic 迴歸分析來研究 UA 與 CKD 之間的相關性。結果多變量二分類 Logistic 迴歸分析顯示,隨著尿痠水平的升高, CKD 的患病風險呈上升趨勢(趨勢檢驗 P<0.05)。在調整瞭年齡,體重,體重指數(body mass index, BMI),血壓、空腹血糖,總膽固醇(total cholesterol, TC),甘油三酯(triglyceride, TG)等影響因素後,與對照 UA 組相比,第2組患 CKD 的相對危險度( OR)為2.54(95% CI：1.51~4.83),第3組患 CKD 的 OR 值為4.65(95% CI：2.73~6.21),第4組患 CKD 的 OR 值為11.68(95% CI：6.41~15.92)。結論 CKD 與高尿痠血癥之間存在相關性,隨著 UA 水平的升高, CKD 的患病風險也逐漸升高。
목적：탐구만성신장질병(chronic kidney disease, CKD)여고뇨산혈증(hyperuricemia)적관련성。방법선취익기산의원신내과198례입원환자작위연구대상,개전횡단면연구。진행신소구려과솔(GFR)적측정(GFR<60 mL/min/1.73 m2정의위 CKD),병수집상관위험인소자료。선용다변량이분류 Logistic 회귀분석래연구 UA 여 CKD 지간적상관성。결과다변량이분류 Logistic 회귀분석현시,수착뇨산수평적승고, CKD 적환병풍험정상승추세(추세검험 P<0.05)。재조정료년령,체중,체중지수(body mass index, BMI),혈압、공복혈당,총담고순(total cholesterol, TC),감유삼지(triglyceride, TG)등영향인소후,여대조 UA 조상비,제2조환 CKD 적상대위험도( OR)위2.54(95% CI：1.51~4.83),제3조환 CKD 적 OR 치위4.65(95% CI：2.73~6.21),제4조환 CKD 적 OR 치위11.68(95% CI：6.41~15.92)。결론 CKD 여고뇨산혈증지간존재상관성,수착 UA 수평적승고, CKD 적환병풍험야축점승고。
Objective To explore the correlation between chronic kidney disease and hyperuicemia. Methods 198 patients from the Nephrology Department in Yijishan Hospital of Wannan Medical College were selected from October 2011 to October 2012. GFR (GFR<60 mL/ min/ 1. 73 m2 defined as CKD) was measured and relative risk factors were collected. Multivariate binary logistic regres-sion was used to analyze the correlation between serum uric acid and CKD. Results With elevated levels of uric acid, the risk of CKD was in an upward trend. After adjusting such influencing factors as age, body weight, body mass index, blood pressure, FBG, TC and TG, the risk rates of CKD, compared with the UA team, in the second, third, and fourth groups were 2. 54 (95% confidence interval (CI), 1. 51 ~ 4. 83), 4. 65 (95% CI, 2. 73 ~ 6. 21), 11. 68 (95% CI, 6. 41 ~ 15. 92) respectively. Conclusion There was corre-lation between high uric acid and chronic kidney disease (CKD). With the increase of UA level, the risk of chronic kidney disease (CKD) is also gradually increased.
